Pretreatment nutritional status and locoregional failure of patients with head and neck cancer undergoing definitive concurrent chemoradiation therapy

• Published in: Head & neck 2011-11, Vol.33 (11), p.1561-1568
• Main Authors: Platek, Mary E., Reid, Mary E., Wilding, Gregory E., Jaggernauth, Wainwright, Rigual, Nestor R., Hicks Jr, Wesley L., Popat, Saurin R., Warren, Graham W., Sullivan, Maureen, Thorstad, Wade L., Khan, Mohamed K., Loree, Thom R., Singh, Anurag K.
• Format: Article
• Language: English
• Subjects: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols - administration & dosage; Biological and medical sciences; Carcinoma, Squamous Cell - mortality; Carcinoma, Squamous Cell - pathology; Carcinoma, Squamous Cell - therapy; Chemoradiotherapy - methods; Cohort Studies; Combined Modality Therapy; concurrent chemoradiation therapy; Confidence Intervals; Dermatology; Disease-Free Survival; Diseases of the digestive system; Female; Head and Neck Neoplasms - mortality; Head and Neck Neoplasms - pathology; Head and Neck Neoplasms - therapy; Humans; ideal body weight; Logistic Models; Male; Medical sciences; Middle Aged; Neoplasm Recurrence, Local - mortality; Neoplasm Recurrence, Local - pathology; Neoplasm Recurrence, Local - therapy; Neoplasm Staging; nutrition; Nutritional Status; Odds Ratio; Otorhinolaryngology (head neck, general aspects and miscellaneous); Otorhinolaryngology. Stomatology; percutaneous endoscopic gastrostomy tube; Predictive Value of Tests; Prognosis; Radiotherapy, Intensity-Modulated - methods; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects); Retrospective Studies; Risk Assessment; Squamous Cell Carcinoma of Head and Neck; squamous cell carcinoma of the head and neck; Survival Analysis; Treatment Failure; Tumors; Tumors of the skin and soft tissue. Premalignant lesions
• ISSN: 1043-3074; 1097-0347
• DOI: 10.1002/hed.21640

Background This study was carried out to determine if markers of nutritional status predict for locoregional failure following intensity‐modulated radiation therapy (IMRT) with concurrent chemoradiotherapy (CCRT) for squamous cell carcinoma of the head and neck (SCCHN). Methods We performed a retrospective chart review of 78 patients with SCCHN who received definitive CCRT. We compared patient factors, tumor characteristics, and nutritional status indicators between patients with and without locoregional failure. Results Fifteen of 78 patients (19%) experienced locoregional failure. Median follow‐up for live patients was 38 months. On univariate analysis, pretreatment percentage of ideal body weight (%IBW) (p < .01), pretreatment hemoglobin (p = .04), and treatment duration (p < .01) were significant predictors of failure. On multivariate analysis, pretreatment %IBW (p = .04) and treatment time (p < .01) remained statistically significant. Conclusions Although treatment time is an accepted risk factor for failure, differences in outcome for patients with head and neck cancer undergoing definitive CCRT based on pretreatment %IBW should be examined further. © 2010 Wiley Periodicals, Inc. Head Neck, 2011