Association between perceived fatigue and gait parameters measured by an instrumented treadmill in people with multiple sclerosis: a cross-sectional study

Multiple sclerosis (MS) is a multi-focal progressive disorder of the central nervous system often resulting in diverse clinical manifestations. Symptomatic fatigue is quite common in people with MS (PwMS), with prevalence as high as 85%. Nevertheless, it remains poorly understood and its association...

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Bibliographic Details
Published in:Journal of neuroengineering and rehabilitation 2015-04, Vol.12 (1), p.34-34, Article 34
Main Author: Kalron, Alon
Format: Article
Language:English
Subjects:
Adult
Analysis
Care and treatment
Complications and side effects
Cross-Sectional Studies
Diagnosis
Exercise equipment
Exercise Test
Fatigue
Fatigue - epidemiology
Fatigue - etiology
Female
Gait - physiology
Gait Disorders, Neurologic - epidemiology
Gait Disorders, Neurologic - etiology
Health aspects
Humans
Male
Middle Aged
Multiple sclerosis
Multiple Sclerosis, Relapsing-Remitting - complications
Risk factors
Surveys and Questionnaires
Walking
Walking - physiology
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Summary:Multiple sclerosis (MS) is a multi-focal progressive disorder of the central nervous system often resulting in diverse clinical manifestations. Symptomatic fatigue is quite common in people with MS (PwMS), with prevalence as high as 85%. Nevertheless, it remains poorly understood and its association with walking capabilities unclear. Therefore, the objective of this investigation was to examine the relationship between symptomatic fatigue and spatio-temporal parameters of gait in PwMS based on an instrumented treadmill. One hundred and twenty-four relapsing-remitting patients diagnosed with MS, 84 women and 40 men aged 42.6 (S.D = 11.9), participated in this investigation. A convenience sample of 25 apparently healthy subjects, 15 women and 10 men aged 40.3 (S.D = 11.1), served as controls. Gait spatiotemporal parameters were obtained using the Zebris FDM-T Treadmill (Zebris1 Medical GmbH, Germany). The Modified Fatigue Impact Scale (MFIS), a self-reported questionnaire, was used to determine the level of symptomatic fatigue in the MS study group. PwMS were divided into two groups: fatigued and non-fatigued. Forty-four PwMS were classified as suffering from fatigue (mean MFIS = 52.0, S.D = 13.7); 80 were classified as non-fatigued (mean MFIS = 14.5, S.D = 14.5). Individuals in the fatigued group walked slower than those in the non-fatigued group; 1.7 (S.D = 2.4) vs. 2.4 (S.D = 1.0); P 
ISSN:1743-0003
1743-0003
DOI:10.1186/s12984-015-0028-2