Apparent diffusion coefficient measurement by diffusion weighted magnetic resonance imaging is a useful tool in differentiating renal tumors

To determine the clinical value of apparent diffusion coefficient (ADC) measurement by diffusion weighted magnetic resonance imaging (DW-MRI) in differentiating renal tumors. Electronic databases were searched using combinations of keywords and free words relating to renal tumor, ADC and DW-MRI. Bas...

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Bibliographic Details
Published in:BMC cancer 2015-04, Vol.15 (1), p.292-292, Article 292
Main Authors: Liu, Jing-Hong, Tian, Shi-Feng, Ju, Ye, Li, Ye, Chen, An-Liang, Chen, Li-Hua, Liu, Ai-Lian
Format: Article
Language:English
Subjects:
Case-Control Studies
Computer software industry
Databases, Factual
Diffusion Magnetic Resonance Imaging - methods
Humans
Kidney Neoplasms - diagnosis
Magnetic resonance imaging
Measurement
Publication Bias
Sensitivity and Specificity
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Summary:To determine the clinical value of apparent diffusion coefficient (ADC) measurement by diffusion weighted magnetic resonance imaging (DW-MRI) in differentiating renal tumors. Electronic databases were searched using combinations of keywords and free words relating to renal tumor, ADC and DW-MRI. Based on carefully selected inclusion and exclusion criteria, relevant case-control studies were identified and the related clinical data was acquired. Statistical analyses were performed using STATA 12.0 (Stata Corporation, College station, TX). Sixteen case-control studies were ultimately included in the present meta-analysis. These 16 high quality studies contained a combined total of 438 normal renal tissues and 832 renal tumor lesions (597 malignant and 235 benign). The results revealed that ADC values of malignant renal tumor tissues were markedly lower than normal renal tissues and benign renal tumor tissues. ADC values of benign renal tumor tissues were also significantly lower than normal renal tissue. ADC measurement by DW-MRI provided clinically useful information on the internal structure of renal tumors and could be an important radiographic index for differentiation of malignant renal tumors from benign renal tumors.
ISSN:1471-2407
1471-2407
DOI:10.1186/s12885-015-1221-1