Effects of exercise in experimental autoimmune encephalomyelitis (an animal model of multiple sclerosis)

Abstract Exercise training has improved many outcomes in “clinical” research involving persons with multiple sclerosis (MS), but there is limited understanding of the underlying “basic” pathophysiological mechanisms. The animal model of MS, experimental autoimmune encephalomyelitis (EAE), seems idea...

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Bibliographic Details
Published in:Journal of neuroimmunology 2014-09, Vol.274 (1), p.14-19
Main Authors: Klaren, Rachel E, Motl, Robert W, Woods, Jeffrey A, Miller, Stephen D
Format: Article
Language:English
Subjects:
Allergy and Immunology
Animals
Disease Models, Animal
Encephalomyelitis, Autoimmune, Experimental - immunology
Encephalomyelitis, Autoimmune, Experimental - physiopathology
Exercise
Experimental autoimmune encephalomyelitis
Mice
Multiple sclerosis
Multiple Sclerosis - immunology
Multiple Sclerosis - physiopathology
Neurology
Physical Conditioning, Animal - physiology
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Summary:Abstract Exercise training has improved many outcomes in “clinical” research involving persons with multiple sclerosis (MS), but there is limited understanding of the underlying “basic” pathophysiological mechanisms. The animal model of MS, experimental autoimmune encephalomyelitis (EAE), seems ideal for examining the effects of exercise training on MS-disease pathophysiology. EAE is an autoimmune T-helper cell-mediated disease characterized by T-cell and monocyte infiltration and inflammation in the CNS. To that end, this paper briefly describes common models of EAE, reviews existing research on exercise and EAE, and then identifies future research directions for understanding the consequences of exercise training using EAE.
ISSN:0165-5728
1872-8421
DOI:10.1016/j.jneuroim.2014.06.014