Optimizing the detection of recent tuberculosis infection in children in a high tuberculosis-HIV burden setting

Children who are young, malnourished, and infected with HIV have significant risk of tuberculosis (TB) morbidity and mortality following TB infection. Treatment of TB infection is hindered by poor detection and limited pediatric data. Identify improved testing to detect pediatric TB infection. This...

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Bibliographic Details
Published in:American journal of respiratory and critical care medicine 2015-04, Vol.191 (7), p.820-830
Main Authors: Mandalakas, Anna M, Kirchner, H Lester, Walzl, Gerhard, Gie, Robert P, Schaaf, H Simon, Cotton, Mark F, Grewal, Harleen M S, Hesseling, Anneke C
Format: Article
Language:English
Subjects:
Adolescent
Child
Child, Preschool
Early Diagnosis
Female
HIV Infections - complications
Humans
Infant
Interferon-gamma Release Tests
Latent Tuberculosis - diagnosis
Latent Tuberculosis - etiology
Male
Mass Screening - methods
Mycobacterium tuberculosis
Original
Prospective Studies
South Africa
Tuberculin Test
Tuberculosis, Pulmonary - diagnosis
Tuberculosis, Pulmonary - etiology
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Summary:Children who are young, malnourished, and infected with HIV have significant risk of tuberculosis (TB) morbidity and mortality following TB infection. Treatment of TB infection is hindered by poor detection and limited pediatric data. Identify improved testing to detect pediatric TB infection. This was a prospective community-based study assessing use of the tuberculin skin test and IFN-γ release assays among children (n = 1,343; 6 mo to
ISSN:1073-449X
1535-4970
1535-4970
DOI:10.1164/rccm.201406-1165OC