Activating killer immunoglobulin‐like receptors genes are associated with increased susceptibility to ankylosing spondylitis

• Published in: Clinical and experimental immunology 2015-05, Vol.180 (2), p.201-206
• Main Authors: Díaz‐Peña, R., Vidal‐Castiñeira, J. R., Mulero, J., Sánchez, A., Queiro, R., López‐Larrea, C.
• Format: Article
• Language: English
• Subjects: ankylosing spondylitis; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Genotyping Techniques; HLA-B27 Antigen - genetics; HLA-B27 Antigen - immunology; HLA‐B27; Humans; KIR; Male; Receptors, KIR - genetics; Receptors, KIR - immunology; Receptors, KIR3DS1 - genetics; Receptors, KIR3DS1 - immunology; Spondylitis, Ankylosing - genetics; Spondylitis, Ankylosing - immunology; Spondylitis, Ankylosing - pathology; susceptibility; Translational
• ISSN: 0009-9104; 1365-2249
• DOI: 10.1111/cei.12568

Summary The aim of this study was to analyse the association of specific killer cell immunoglobulin‐like receptors (KIR) genes and haplotypes with susceptibility to ankylosing spondylitis (AS) and its different clinical manifestations in a Spanish population. The presence or absence of all KIR genes was studied for their association with AS. A total of 176 patients with AS and 435 healthy control subjects were selected for this study based on clinical criteria. The commercial KIR‐sequence‐specific oligonucleotides (SSO) typing kit was used to investigate KIR typing. Frequencies of KIR2DS1 and KIR3DS1 genes were increased significantly in patients compared with healthy controls [52·8 versus 38·2%, PBonf < 0·01, odds ratio (OR) = 1·81 (1·28–2·59); 51·7 versus 37·5%, PBonf < 0·01, OR = 1·79 (1·25–2·54)]. Moreover, the frequency of activating genotypes in the AS patient group was significantly higher than in the healthy control group (P