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Activating killer immunoglobulin‐like receptors genes are associated with increased susceptibility to ankylosing spondylitis
Summary The aim of this study was to analyse the association of specific killer cell immunoglobulin‐like receptors (KIR) genes and haplotypes with susceptibility to ankylosing spondylitis (AS) and its different clinical manifestations in a Spanish population. The presence or absence of all KIR genes...
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| Published in: | Clinical and experimental immunology 2015-05, Vol.180 (2), p.201-206 |
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| creator | Díaz‐Peña, R. Vidal‐Castiñeira, J. R. Mulero, J. Sánchez, A. Queiro, R. López‐Larrea, C. |
| description | Summary
The aim of this study was to analyse the association of specific killer cell immunoglobulin‐like receptors (KIR) genes and haplotypes with susceptibility to ankylosing spondylitis (AS) and its different clinical manifestations in a Spanish population. The presence or absence of all KIR genes was studied for their association with AS. A total of 176 patients with AS and 435 healthy control subjects were selected for this study based on clinical criteria. The commercial KIR‐sequence‐specific oligonucleotides (SSO) typing kit was used to investigate KIR typing. Frequencies of KIR2DS1 and KIR3DS1 genes were increased significantly in patients compared with healthy controls [52·8 versus 38·2%, PBonf < 0·01, odds ratio (OR) = 1·81 (1·28–2·59); 51·7 versus 37·5%, PBonf < 0·01, OR = 1·79 (1·25–2·54)]. Moreover, the frequency of activating genotypes in the AS patient group was significantly higher than in the healthy control group (P |
| doi_str_mv | 10.1111/cei.12568 |
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The aim of this study was to analyse the association of specific killer cell immunoglobulin‐like receptors (KIR) genes and haplotypes with susceptibility to ankylosing spondylitis (AS) and its different clinical manifestations in a Spanish population. The presence or absence of all KIR genes was studied for their association with AS. A total of 176 patients with AS and 435 healthy control subjects were selected for this study based on clinical criteria. The commercial KIR‐sequence‐specific oligonucleotides (SSO) typing kit was used to investigate KIR typing. Frequencies of KIR2DS1 and KIR3DS1 genes were increased significantly in patients compared with healthy controls [52·8 versus 38·2%, PBonf < 0·01, odds ratio (OR) = 1·81 (1·28–2·59); 51·7 versus 37·5%, PBonf < 0·01, OR = 1·79 (1·25–2·54)]. Moreover, the frequency of activating genotypes in the AS patient group was significantly higher than in the healthy control group (P < 0·05). KIR2DS1 and KIR3DS1, in addition to human leucocyte antigen (HLA)‐B27, may play an important role in the pathogenesis of AS. However, we show that the contribution of the KIR genes to AS susceptibility extends beyond the association with individual KIRs, with an imbalance between activating and inhibitory KIR genes seeming to influence the susceptibility to AS.</description><identifier>ISSN: 0009-9104</identifier><identifier>EISSN: 1365-2249</identifier><identifier>DOI: 10.1111/cei.12568</identifier><identifier>PMID: 25491925</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>ankylosing spondylitis ; Female ; Gene Frequency ; Genetic Predisposition to Disease ; Genotype ; Genotyping Techniques ; HLA-B27 Antigen - genetics ; HLA-B27 Antigen - immunology ; HLA‐B27 ; Humans ; KIR ; Male ; Receptors, KIR - genetics ; Receptors, KIR - immunology ; Receptors, KIR3DS1 - genetics ; Receptors, KIR3DS1 - immunology ; Spondylitis, Ankylosing - genetics ; Spondylitis, Ankylosing - immunology ; Spondylitis, Ankylosing - pathology ; susceptibility ; Translational</subject><ispartof>Clinical and experimental immunology, 2015-05, Vol.180 (2), p.201-206</ispartof><rights>2014 British Society for Immunology</rights><rights>2014 British Society for Immunology.</rights><rights>2015 British Society for Immunology</rights><rights>2014 British Society for Immunology 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4768-6068e91c223763b3eddb874482b5734bcf6e86c3399ea6fa0fd1d4dd8837f3453</citedby><cites>FETCH-LOGICAL-c4768-6068e91c223763b3eddb874482b5734bcf6e86c3399ea6fa0fd1d4dd8837f3453</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4408154/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4408154/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25491925$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Díaz‐Peña, R.</creatorcontrib><creatorcontrib>Vidal‐Castiñeira, J. R.</creatorcontrib><creatorcontrib>Mulero, J.</creatorcontrib><creatorcontrib>Sánchez, A.</creatorcontrib><creatorcontrib>Queiro, R.</creatorcontrib><creatorcontrib>López‐Larrea, C.</creatorcontrib><title>Activating killer immunoglobulin‐like receptors genes are associated with increased susceptibility to ankylosing spondylitis</title><title>Clinical and experimental immunology</title><addtitle>Clin Exp Immunol</addtitle><description>Summary
The aim of this study was to analyse the association of specific killer cell immunoglobulin‐like receptors (KIR) genes and haplotypes with susceptibility to ankylosing spondylitis (AS) and its different clinical manifestations in a Spanish population. The presence or absence of all KIR genes was studied for their association with AS. A total of 176 patients with AS and 435 healthy control subjects were selected for this study based on clinical criteria. The commercial KIR‐sequence‐specific oligonucleotides (SSO) typing kit was used to investigate KIR typing. Frequencies of KIR2DS1 and KIR3DS1 genes were increased significantly in patients compared with healthy controls [52·8 versus 38·2%, PBonf < 0·01, odds ratio (OR) = 1·81 (1·28–2·59); 51·7 versus 37·5%, PBonf < 0·01, OR = 1·79 (1·25–2·54)]. Moreover, the frequency of activating genotypes in the AS patient group was significantly higher than in the healthy control group (P < 0·05). KIR2DS1 and KIR3DS1, in addition to human leucocyte antigen (HLA)‐B27, may play an important role in the pathogenesis of AS. However, we show that the contribution of the KIR genes to AS susceptibility extends beyond the association with individual KIRs, with an imbalance between activating and inhibitory KIR genes seeming to influence the susceptibility to AS.</description><subject>ankylosing spondylitis</subject><subject>Female</subject><subject>Gene Frequency</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype</subject><subject>Genotyping Techniques</subject><subject>HLA-B27 Antigen - genetics</subject><subject>HLA-B27 Antigen - immunology</subject><subject>HLA‐B27</subject><subject>Humans</subject><subject>KIR</subject><subject>Male</subject><subject>Receptors, KIR - genetics</subject><subject>Receptors, KIR - immunology</subject><subject>Receptors, KIR3DS1 - genetics</subject><subject>Receptors, KIR3DS1 - immunology</subject><subject>Spondylitis, Ankylosing - genetics</subject><subject>Spondylitis, Ankylosing - immunology</subject><subject>Spondylitis, Ankylosing - pathology</subject><subject>susceptibility</subject><subject>Translational</subject><issn>0009-9104</issn><issn>1365-2249</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNqNks1qFTEUx4Mo9lpd-AIScKOLafM1mclGKJeqhYIbXYdM5sxtejPJNZlpmY34CD6jT2KutxYVBLM5HM6Pf87HH6HnlJzQ8k4tuBPKatk-QCvKZV0xJtRDtCKEqEpRIo7Qk5yvSyqlZI_REauFoorVK_TlzE7uxkwubPDWeQ8Ju3GcQ9z42M3ehe9fv3m3BZzAwm6KKeMNBMjYJMAm52idmaDHt266wi7YBCaXNM95j7vOeTcteIrYhO3iY97_k3cx9EspuPwUPRqMz_DsLh6jT2_PP67fV5cf3l2szy4rKxrZVpLIFhS1jPFG8o5D33dtI0TLurrhorODhFZazpUCIwdDhp72ou_bljcDFzU_Rm8Ouru5G6G3EKZkvN4lN5q06Gic_rMS3JXexBstBGlpLYrAqzuBFD_PkCc9ujKi9yZAnLOmsjQma0bI_6C8UYzVtKAv_0Kv45xC2cSeYooyKmShXh8om2LOCYb7vinRewPoYgD90wCFffH7oPfkr4sX4PQA3DoPy7-V9Pr84iD5A1Khvqo</recordid><startdate>201505</startdate><enddate>201505</enddate><creator>Díaz‐Peña, R.</creator><creator>Vidal‐Castiñeira, J. R.</creator><creator>Mulero, J.</creator><creator>Sánchez, A.</creator><creator>Queiro, R.</creator><creator>López‐Larrea, C.</creator><general>Oxford University Press</general><general>BlackWell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>M7N</scope><scope>7X8</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>5PM</scope></search><sort><creationdate>201505</creationdate><title>Activating killer immunoglobulin‐like receptors genes are associated with increased susceptibility to ankylosing spondylitis</title><author>Díaz‐Peña, R. ; Vidal‐Castiñeira, J. R. ; Mulero, J. ; Sánchez, A. ; Queiro, R. ; López‐Larrea, C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4768-6068e91c223763b3eddb874482b5734bcf6e86c3399ea6fa0fd1d4dd8837f3453</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>ankylosing spondylitis</topic><topic>Female</topic><topic>Gene Frequency</topic><topic>Genetic Predisposition to Disease</topic><topic>Genotype</topic><topic>Genotyping Techniques</topic><topic>HLA-B27 Antigen - genetics</topic><topic>HLA-B27 Antigen - immunology</topic><topic>HLA‐B27</topic><topic>Humans</topic><topic>KIR</topic><topic>Male</topic><topic>Receptors, KIR - genetics</topic><topic>Receptors, KIR - immunology</topic><topic>Receptors, KIR3DS1 - genetics</topic><topic>Receptors, KIR3DS1 - immunology</topic><topic>Spondylitis, Ankylosing - genetics</topic><topic>Spondylitis, Ankylosing - immunology</topic><topic>Spondylitis, Ankylosing - pathology</topic><topic>susceptibility</topic><topic>Translational</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Díaz‐Peña, R.</creatorcontrib><creatorcontrib>Vidal‐Castiñeira, J. R.</creatorcontrib><creatorcontrib>Mulero, J.</creatorcontrib><creatorcontrib>Sánchez, A.</creatorcontrib><creatorcontrib>Queiro, R.</creatorcontrib><creatorcontrib>López‐Larrea, C.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Clinical and experimental immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Díaz‐Peña, R.</au><au>Vidal‐Castiñeira, J. R.</au><au>Mulero, J.</au><au>Sánchez, A.</au><au>Queiro, R.</au><au>López‐Larrea, C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Activating killer immunoglobulin‐like receptors genes are associated with increased susceptibility to ankylosing spondylitis</atitle><jtitle>Clinical and experimental immunology</jtitle><addtitle>Clin Exp Immunol</addtitle><date>2015-05</date><risdate>2015</risdate><volume>180</volume><issue>2</issue><spage>201</spage><epage>206</epage><pages>201-206</pages><issn>0009-9104</issn><eissn>1365-2249</eissn><abstract>Summary
The aim of this study was to analyse the association of specific killer cell immunoglobulin‐like receptors (KIR) genes and haplotypes with susceptibility to ankylosing spondylitis (AS) and its different clinical manifestations in a Spanish population. The presence or absence of all KIR genes was studied for their association with AS. A total of 176 patients with AS and 435 healthy control subjects were selected for this study based on clinical criteria. The commercial KIR‐sequence‐specific oligonucleotides (SSO) typing kit was used to investigate KIR typing. Frequencies of KIR2DS1 and KIR3DS1 genes were increased significantly in patients compared with healthy controls [52·8 versus 38·2%, PBonf < 0·01, odds ratio (OR) = 1·81 (1·28–2·59); 51·7 versus 37·5%, PBonf < 0·01, OR = 1·79 (1·25–2·54)]. Moreover, the frequency of activating genotypes in the AS patient group was significantly higher than in the healthy control group (P < 0·05). KIR2DS1 and KIR3DS1, in addition to human leucocyte antigen (HLA)‐B27, may play an important role in the pathogenesis of AS. However, we show that the contribution of the KIR genes to AS susceptibility extends beyond the association with individual KIRs, with an imbalance between activating and inhibitory KIR genes seeming to influence the susceptibility to AS.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>25491925</pmid><doi>10.1111/cei.12568</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Clinical and experimental immunology, 2015-05, Vol.180 (2), p.201-206 |
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| subjects | ankylosing spondylitis Female Gene Frequency Genetic Predisposition to Disease Genotype Genotyping Techniques HLA-B27 Antigen - genetics HLA-B27 Antigen - immunology HLA‐B27 Humans KIR Male Receptors, KIR - genetics Receptors, KIR - immunology Receptors, KIR3DS1 - genetics Receptors, KIR3DS1 - immunology Spondylitis, Ankylosing - genetics Spondylitis, Ankylosing - immunology Spondylitis, Ankylosing - pathology susceptibility Translational |
| title | Activating killer immunoglobulin‐like receptors genes are associated with increased susceptibility to ankylosing spondylitis |
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