Per a 10 protease activity modulates CD40 expression on dendritic cell surface by nuclear factor‐kappaB pathway

Summary Serine protease activity of Per a 10 from Periplaneta americana modulates dendritic cell (DC) functions by a mechanism(s) that remains unclear. In the present study, Per a 10 protease activity on CD40 expression and downstream signalling was evaluated in DCs. Monocyte‐derived DCs from cockro...

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Bibliographic Details
Published in:Clinical and experimental immunology 2015-05, Vol.180 (2), p.341-351
Main Authors: Goel, C., Kalra, N., Dwarakanath, B. S., Gaur, S. N., Arora, N.
Format: Article
Language:English
Subjects:
Adult
allergen
Animals
Basic Science
CD4-Positive T-Lymphocytes - immunology
CD40
CD40 Antigens - immunology
Cytokines - immunology
dendritic cell
Dendritic Cells - immunology
Dendritic Cells - pathology
Female
Humans
Insect Proteins - immunology
Male
NF-kappa B - immunology
Peptide Hydrolases - immunology
Per a 10
Periplaneta - immunology
Periplaneta americana
proteolytic activity
Signal Transduction - immunology
TNF Receptor-Associated Factor 6 - immunology
Up-Regulation - immunology
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Summary:Summary Serine protease activity of Per a 10 from Periplaneta americana modulates dendritic cell (DC) functions by a mechanism(s) that remains unclear. In the present study, Per a 10 protease activity on CD40 expression and downstream signalling was evaluated in DCs. Monocyte‐derived DCs from cockroach‐allergic patients were treated with proteolytically active/heat‐inactivated Per a 10. Stimulation with active Per a 10 demonstrated low CD40 expression on DCs surface (P 
ISSN:0009-9104
1365-2249
DOI:10.1111/cei.12569