Effect of the beta-3 adrenergic receptor Trp64Arg and uncoupling protein 1-3826 A>G genotypes on lipid and apolipoprotein levels in overweight/obese and non-obese Chinese subjects

The beta-3 adrenergic receptor (β3-AR) Trp64Arg and uncoupling protein 1 (UCP1) -3826 A>G polymorphisms have been reported to be associated with obesity and/or lipid metabolism in some populations. This study examined the possible association of the β3-AR and UCP1 polymorphisms with overweight/ob...

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Published in:Lipids in health and disease 2015-04, Vol.14 (1), p.34-34, Article 34
Main Authors: Chen, Yihong, Wang, Xiaosu, Shen, Zheni, Fan, Ping, Liu, Rui, Liu, Yu, Ren, Rongmei, Ma, Lei, Bai, Huai
Format: Article
Language:English
Subjects:
Analysis
Apolipoproteins
Apolipoproteins - blood
Asian Continental Ancestry Group - genetics
Case-Control Studies
China
Cholesterol - blood
Cholesterol, HDL - blood
Female
Gene Frequency - genetics
Genetic aspects
Genetic Association Studies
Genetic polymorphisms
Humans
Ion Channels - genetics
Lipids - blood
Male
Middle Aged
Mitochondrial Proteins - genetics
Obesity - blood
Obesity - genetics
Overweight - blood
Overweight - genetics
Physiological aspects
Polymorphism, Genetic - genetics
Receptors, Adrenergic, beta-3 - genetics
Triglycerides - blood
Uncoupling Protein 1
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Summary:The beta-3 adrenergic receptor (β3-AR) Trp64Arg and uncoupling protein 1 (UCP1) -3826 A>G polymorphisms have been reported to be associated with obesity and/or lipid metabolism in some populations. This study examined the possible association of the β3-AR and UCP1 polymorphisms with overweight/obesity or lipid variation in a Southwest Chinese population. A total of 418 Han Chinese (249 overweight/obese and 169 healthy control subjects) in the Chengdu area were studied using PCR-RFLP analysis. Total serum cholesterol (TC) and triglycerides (TGs) were measured using an enzymatic method. High density lipoprotein cholesterol (HDL-C) was determined after sodium phosphotungstate/magnesium chloride precipitation of low-density lipoproteins by polyvinyl sulfate. Serum apolipoproteins were quantified by radial immunodiffusion. The genotype and allele frequencies of the β3-AR Trp64Arg and UCP1 -3826 A>G polymorphisms in overweight/obese subjects exhibited no significant differences compared to the controls. However, subjects carrying the β3-AR TrpTrp genotype and UCP1 AG genotype had higher TG levels than those carrying the Arg allele and AA genotype, respectively (P
ISSN:1476-511X
1476-511X
DOI:10.1186/s12944-015-0029-y