Hypothalamic-amygdalar-brainstem volume reduction in a patient with narcolepsy secondary to diffuse axonal injury

A 17-year-old male with diffuse axonal injury (DAI) was referred to our psychiatric clinic with a diagnosis of depression. However, further investigation indicated that he had narcolepsy without cataplexy secondary to DAI. We assessed regional volume alterations in the patient; MRI analysis showed a...

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Bibliographic Details
Published in:Journal of clinical sleep medicine 2015-05, Vol.11 (5), p.581-582
Main Authors: Yassin, Walid, Sugihara, Genichi, Oishi, Naoya, Kubota, Manabu, Ubukata, Shiho, Murai, Toshiya, Ueda, Keita
Format: Article
Language:English
Subjects:
Adolescent
Amygdala - pathology
Brain Stem - pathology
Case Reports
Diffuse Axonal Injury - complications
Diffuse Axonal Injury - pathology
Humans
Hypothalamus - pathology
Magnetic Resonance Imaging
Male
Narcolepsy - etiology
Narcolepsy - pathology
Organ Size
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Summary:A 17-year-old male with diffuse axonal injury (DAI) was referred to our psychiatric clinic with a diagnosis of depression. However, further investigation indicated that he had narcolepsy without cataplexy secondary to DAI. We assessed regional volume alterations in the patient; MRI analysis showed a significant decrease in the volume of the hypothalamus, left amygdala, and brainstem. Our findings add to further understanding of the structural basis of secondary narcolepsy, and may provide basis for future neuroimaging studies on sleep disturbances in traumatic brain injury (TBI).
ISSN:1550-9389
1550-9397
DOI:10.5664/jcsm.4710