Development of the zebrafish mesonephros

Summary The vertebrate kidney plays an essential role in removing metabolic waste and balancing water and salt. This is carried out by nephrons, which comprise a blood filter attached to an epithelial tubule with proximal and distal segments. In zebrafish, two nephrons are first formed as part of th...

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Published in:Genesis (New York, N.Y. : 2000) N.Y. : 2000), 2015-03, Vol.53 (3-4), p.257-269
Main Authors: Diep, Cuong Q., Peng, Zhenzhen, Ukah, Tobechukwu K., Kelly, Paul M., Daigle, Renee V., Davidson, Alan J.
Format: Article
Language:English
Subjects:
Animals
Danio rerio
Embryo, Nonmammalian - cytology
Embryo, Nonmammalian - physiology
Freshwater
Gene Expression Regulation, Developmental
Immunoenzyme Techniques
In Situ Hybridization
kidney
Kidney - embryology
Kidney - metabolism
Mesonephros - embryology
Mesonephros - metabolism
Metamorphosis, Biological
nephron
Nephrons - embryology
Nephrons - metabolism
Organogenesis - physiology
pronephros
Pronephros - embryology
Pronephros - metabolism
Zebrafish - embryology
Zebrafish - genetics
Zebrafish - metabolism
Zebrafish Proteins - metabolism
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Summary:Summary The vertebrate kidney plays an essential role in removing metabolic waste and balancing water and salt. This is carried out by nephrons, which comprise a blood filter attached to an epithelial tubule with proximal and distal segments. In zebrafish, two nephrons are first formed as part of the embryonic kidney (pronephros) and hundreds are formed later to make up the adult kidney (mesonephros). Previous studies have focused on the development of the pronephros while considerably less is known about how the mesonephros is formed. Here, we characterize mesonephros development in zebrafish and examine the nephrons that form during larval metamorphosis. These nephrons, arising from proliferating progenitor cells that express the renal transcription factor genes wt1b, pax2a, and lhx1a, form on top of the pronephric tubules and develop a segmentation pattern similar to pronephric nephrons. We find that the pronephros acts as a scaffold for the mesonephros, where new nephrons fuse with the distal segments of the pronephric tubules to form the final branching network that characterizes the adult zebrafish kidney. genesis 53:257–269, 2015. © 2015 Wiley Periodicals, Inc.
ISSN:1526-954X
1526-968X
DOI:10.1002/dvg.22846