B7-H1 and B7-H3 are independent predictors of poor prognosis in patients with non-small cell lung cancer

• Published in: Oncotarget 2015-02, Vol.6 (5), p.3452-3461
• Main Authors: Mao, Yixiang, Li, Wei, Chen, Kai, Xie, Yufeng, Liu, Qiang, Yao, Min, Duan, Weiming, Zhou, Xiumin, Liang, Rongrui, Tao, Min
• Format: Article
• Language: English
• Subjects: B7 Antigens - genetics; B7 Antigens - metabolism; B7-H1 Antigen - genetics; B7-H1 Antigen - metabolism; Biomarkers, Tumor - genetics; Biomarkers, Tumor - metabolism; Carcinoma, Non-Small-Cell Lung - immunology; Carcinoma, Non-Small-Cell Lung - metabolism; Carcinoma, Non-Small-Cell Lung - mortality; Carcinoma, Non-Small-Cell Lung - secondary; Cell Line, Tumor; Cell Proliferation; Chemotaxis; Clinical Research Paper; Female; Gene Knockdown Techniques; Humans; Interferon-gamma - metabolism; Kaplan-Meier Estimate; Lung Neoplasms - immunology; Lung Neoplasms - metabolism; Lung Neoplasms - mortality; Lung Neoplasms - pathology; Lymphatic Metastasis; Lymphocyte Activation; Lymphocytes, Tumor-Infiltrating - immunology; Lymphocytes, Tumor-Infiltrating - metabolism; Male; Middle Aged; Multivariate Analysis; Neoplasm Staging; Predictive Value of Tests; Proportional Hazards Models; Receptors, CXCR4 - metabolism; Risk Factors; Signal Transduction; T-Lymphocytes - immunology; T-Lymphocytes - metabolism; Transfection; Up-Regulation
• ISSN: 1949-2553; 1949-2553
• DOI: 10.18632/oncotarget.3097

B7-H1 and B7-H3, two members of the B7 family that are thought to regulate T-cell activation, are expressed in human non-small cell lung cancer (NSCLC). However, their prognostic significance is poorly understood. In the present study we reported that B7-H1 and B7-H3 were expressed in 96/128 (72.7%) and 89/128 (69.5%) samples, respectively. B7-H1 and B7-H3 expression and the number of infiltrating T-cell intracellular antigen-1+ and interferon-γ+ cells in NSCLC tissues were significantly higher than those in the adjacent tissues (p