Prognostic Value of Galectin-3 in Patients with Heart Failure

Galectins are a family of soluble β-galactoside-binding lectins that have important role in inflammation, immunity, and cancer. Galectin-3 as a part of this lectin family plays a very important role in development of heart failure. According to recent papers, galectin-3 plasma level correlates with...

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Bibliographic Details
Published in:Disease markers 2015-01, Vol.2015 (2015), p.1-6
Main Authors: Bošnjak, Ivica, Včev, Aleksandar, Selthofer-Relatić, Kristina
Format: Article
Language:English
Subjects:
Animals
Biomarkers - blood
Biomarkers - metabolism
Care and treatment
Development and progression
Galectin 3 - blood
Galectin 3 - metabolism
Genetic aspects
Heart failure
Heart Failure - blood
Heart Failure - metabolism
Humans
Lectins
Properties
Review
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Summary:Galectins are a family of soluble β-galactoside-binding lectins that have important role in inflammation, immunity, and cancer. Galectin-3 as a part of this lectin family plays a very important role in development of heart failure. According to recent papers, galectin-3 plasma level correlates with heart failure outcome, primarily with rehospitalisation and death from heart failure. This paper summarizes the most recent advances in galectin-3 research, with the accent on the role of galectin-3 in pathophysiology of myocardial remodelling and heart failure development—with preserved and reduced ejection fraction, and some implication on development of new disease modifying drugs.
ISSN:0278-0240
1875-8630
DOI:10.1155/2015/690205