Neural Regulation of Hematopoiesis, Inflammation, and Cancer

Although the function of the autonomic nervous system (ANS) in mediating the flight-or-fight response was recognized decades ago, the crucial role of peripheral innervation in regulating cell behavior and response to the microenvironment has only recently emerged. In the hematopoietic system, the AN...

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Bibliographic Details
Published in:Neuron (Cambridge, Mass.) Mass.), 2015-04, Vol.86 (2), p.360-373
Main Authors: Hanoun, Maher, Maryanovich, Maria, Arnal-Estapé, Anna, Frenette, Paul S.
Format: Article
Language:English
Subjects:
Autonomic Nervous System - physiology
Autonomic Nervous System - physiopathology
Autonomic Nervous System Diseases - epidemiology
Bone marrow
Bone Marrow - innervation
Cancer
Cancer therapies
Cell adhesion & migration
Comorbidity
Depression - epidemiology
Gene expression
Hematopoiesis - physiology
Homeostasis
Homeostasis - physiology
Humans
Inflammation - epidemiology
Inflammation - physiopathology
Leukemia, Myeloid - epidemiology
Leukemia, Myeloid - physiopathology
Neoplasms - epidemiology
Neoplasms - physiopathology
Nervous system
Neuropeptides - secretion
Neurotransmitter Agents - secretion
Spinal cord
Stem cells
Stress, Psychological - epidemiology
Studies
Survival Rate
Transplants & implants
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Summary:Although the function of the autonomic nervous system (ANS) in mediating the flight-or-fight response was recognized decades ago, the crucial role of peripheral innervation in regulating cell behavior and response to the microenvironment has only recently emerged. In the hematopoietic system, the ANS regulates stem cell niche homeostasis and regeneration and fine-tunes the inflammatory response. Additionally, emerging data suggest that cancer cells take advantage of innervating neural circuitry to promote their progression. These new discoveries outline the need to redesign therapeutic strategies to target this underappreciated stromal constituent. Here, we review the importance of neural signaling in hematopoietic homeostasis, inflammation, and cancer. Hanoun et al. review how neural signals regulate hematopoietic homeostasis and the inflammatory response and discuss the impact of the autonomous nervous system in cancer progression.
ISSN:0896-6273
1097-4199
DOI:10.1016/j.neuron.2015.01.026