A general review of major global coagulation assays: thrombelastography, thrombin generation test and clot waveform analysis

Thrombosis and hemorrhage are major contributors to morbidity and mortality. The traditional laboratory tests do not supply enough information to diagnose and treat patients timely and according to their phenotype. Global hemostasis tests might improve this circumstance. The viscoelastic tests (ROTE...

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Bibliographic Details
Published in:Thrombosis journal 2015-01, Vol.13 (1), p.1-1, Article 1
Main Author: Lancé, Marcus D
Format: Article
Language:English
Subjects:
Analysis
Blood clot
Care and treatment
Diagnosis
Health aspects
Hemophilia
Mortality
Review
Thrombin
Thrombosis
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Summary:Thrombosis and hemorrhage are major contributors to morbidity and mortality. The traditional laboratory tests do not supply enough information to diagnose and treat patients timely and according to their phenotype. Global hemostasis tests might improve this circumstance. The viscoelastic tests (ROTEM/TEG) demonstrated to ameliorate treatment of acute hemorrhage in terms of decreased amount of transfusion and lowered costs. Thrombin generation measurement is indicative for thrombosis and might also become an important tool in managing hemorrhage. While the clot waveform analysis is less well known it could be of worth in staging sepsis patients, early detection of DIC and also in diagnosis and treatment monitoring of hemophiliac patients. Although in different degree all three methods still need more background, standardization and acceptance before a wide clinical application.
ISSN:1477-9560
1477-9560
DOI:10.1186/1477-9560-13-1