Recycled interleukin-7 can be delivered to neighboring T cells

Interleukin-7 (IL-7) is a key homeostatic cytokine that provides signals for T cell survival and proliferation in vivo . Here, we provide evidence that IL-7 utilization is enhanced by a novel mechanism of cytokine “recycling” during which T cells treated with rIL-7 are rapidly induced to express P-S...

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Bibliographic Details
Published in:The Journal of immunology (1950) 2015-04, Vol.194 (10), p.4698-4704
Main Authors: Bazdar, Douglas A., Kalinowska, Magdalena, Panigrahi, Soumya, Sieg, Scott F.
Format: Article
Language:English
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Summary:Interleukin-7 (IL-7) is a key homeostatic cytokine that provides signals for T cell survival and proliferation in vivo . Here, we provide evidence that IL-7 utilization is enhanced by a novel mechanism of cytokine “recycling” during which T cells treated with rIL-7 are rapidly induced to express P-STAT5 and are subsequently able to recycle biologically active cytokine for release to neighboring cells in soluble form. Our observations indicate that the ability of cells to recycle IL-7 is dependent on IL-7 receptor alpha chain (CD127) and endocytosis, consistent with a model whereby IL-7 is internalized via receptor interactions prior to recycling. These observations provide evidence of a novel mechanism that enables cells to optimally utilize IL-7.
ISSN:0022-1767
1550-6606
DOI:10.4049/jimmunol.1400560