Genetics of the dentofacial variation in human malocclusion

Malocclusions affect individuals worldwide, resulting in compromised function and esthetics. Understanding the etiological factors contributing to the variation in dentofacial morphology associated with malocclusions is the key to develop novel treatment approaches. Advances in dentofacial phenotypi...

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Bibliographic Details
Published in:Orthodontics & craniofacial research 2015-04, Vol.18 (S1), p.91-99
Main Authors: Moreno Uribe, L. M., Miller, S. F.
Format: Article
Language:English
Subjects:
Anatomic Variation - genetics
candidate genes
cephalometry
craniofacial
Dentistry
Genetic Variation - genetics
Genetics
genomic medicine
Genomics
Genotype
genotype-phenotype correlation
Humans
Malocclusion - genetics
Malocclusion - pathology
Malocclusion, Angle Class II - genetics
Malocclusion, Angle Class II - pathology
Malocclusion, Angle Class III - genetics
Malocclusion, Angle Class III - pathology
phenomics
Phenotype
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Summary:Malocclusions affect individuals worldwide, resulting in compromised function and esthetics. Understanding the etiological factors contributing to the variation in dentofacial morphology associated with malocclusions is the key to develop novel treatment approaches. Advances in dentofacial phenotyping, which is the comprehensive characterization of hard and soft tissue variation in the craniofacial complex, together with the acquisition of large‐scale genomic data have started to unravel genetic mechanisms underlying facial variation. Knowledge on the genetics of human malocclusion is limited even though results attained thus far are encouraging, with promising opportunities for future research. This review summarizes the most common dentofacial variations associated with malocclusions and reviews the current knowledge of the roles of genes in the development of malocclusions. Lastly, this review will describe ways to advance malocclusion research, following examples from the expanding fields of phenomics and genomic medicine, which aim to better patient outcomes.
ISSN:1601-6335
1601-6343
DOI:10.1111/ocr.12083