Weber-Christian disease with ileocolonic involvement successfully treated with infliximab

Weber-Christian disease (WCD) is an inflammatory disease whose main histological feature is lobular panniculitis of adipose tissue. The location of panniculitis determines the clinical presentation, being the subcutaneous adipose tissue the most frequent one, followed by liver, spleen, bone marrow a...

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Bibliographic Details
Published in:World journal of gastroenterology : WJG 2015-05, Vol.21 (17), p.5417-5420
Main Authors: Miranda-Bautista, José, Fernández-Simón, Alejandro, Pérez-Sánchez, Isabel, Menchén, Luis
Format: Article
Language:English
Subjects:
Adult
Anti-Infective Agents - therapeutic use
Biopsy
Case Report
Colonic Diseases - diagnosis
Colonic Diseases - drug therapy
Colonic Diseases - surgery
Female
Humans
Ileal Diseases - diagnosis
Ileal Diseases - drug therapy
Ileal Diseases - surgery
Infliximab - therapeutic use
Panniculitis, Nodular Nonsuppurative - diagnosis
Panniculitis, Nodular Nonsuppurative - drug therapy
Panniculitis, Nodular Nonsuppurative - surgery
Recurrence
Remission Induction
Thalidomide - therapeutic use
Tomography, X-Ray Computed
Treatment Outcome
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Summary:Weber-Christian disease (WCD) is an inflammatory disease whose main histological feature is lobular panniculitis of adipose tissue. The location of panniculitis determines the clinical presentation, being the subcutaneous adipose tissue the most frequent one, followed by liver, spleen, bone marrow and mesenteric adipose tissue. Systemic corticosteroids are first line treatment, but other options should be considered if systemic symptoms are observed or in case of refractory clinical situation. We report herein a case with WCD showing orbital, mesenteric and ileocolonic involvement, which required surgical treatment and also developed postoperative recurrence. Symptoms were resolved by administration of thalidomide and, afterwards, infliximab. To our knowledge, this is the first report of Weber-Christian disease with luminal ileocolonic involvement, treated with infliximab.
ISSN:1007-9327
2219-2840
DOI:10.3748/wjg.v21.i17.5417