Biomaterials for Pelvic Floor Reconstructive Surgery: How Can We Do Better?

Stress urinary incontinence (SUI) and pelvic organ prolapse (POP) are major health issues that detrimentally impact the quality of life of millions of women worldwide. Surgical repair is an effective and durable treatment for both conditions. Over the past two decades there has been a trend to enfor...

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Bibliographic Details
Published in:BioMed research international 2015-01, Vol.2015 (2015), p.1-20
Main Authors: MacNeil, Sheila, Bullock, Anthony J., Bissoli, Julio, Osman, Nadir I., Roman Regueros, Sabiniano, Gigliobianco, Giulia, Chapple, Christopher R.
Format: Article
Language:English
Subjects:
Biocompatible Materials - therapeutic use
Biological materials
Biomaterials
Biomedical materials
Care and treatment
Durability
Failure
Female
Hernias
Hospitals
Humans
Implantation
Inflammatory response
Materials
Mechanical properties
Methods
Patients
Pelvic floor
Pelvic Floor - physiopathology
Pelvic Floor - surgery
Pelvic Organ Prolapse - pathology
Pelvic Organ Prolapse - surgery
Performance evaluation
Physiological aspects
Plastic Surgery Procedures
Prolapse
Repair
Review
Studies
Surgery, Plastic
Surgical implants
Surgical Mesh
Transplants & implants
Treatment Outcome
Urinary incontinence
Urinary Incontinence, Stress - pathology
Urinary Incontinence, Stress - surgery
Women
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Description
Summary:Stress urinary incontinence (SUI) and pelvic organ prolapse (POP) are major health issues that detrimentally impact the quality of life of millions of women worldwide. Surgical repair is an effective and durable treatment for both conditions. Over the past two decades there has been a trend to enforce or reinforce repairs with synthetic and biological materials. The determinants of surgical outcome are many, encompassing the physical and mechanical properties of the material used, and individual immune responses, as well surgical and constitutional factors. Of the current biomaterials in use none represents an ideal. Biomaterials that induce limited inflammatory response followed by constructive remodelling appear to have more long term success than biomaterials that induce chronic inflammation, fibrosis and encapsulation. In this review we draw upon published animal and human studies to characterize the changes biomaterials undergo after implantation and the typical host responses, placing these in the context of clinical outcomes.
ISSN:2314-6133
2314-6141
DOI:10.1155/2015/968087