Striatal Blood–Brain Barrier Permeability in Parkinson'S Disease

In vivo studies have shown that blood–brain barrier (BBB) dysfunction is involved in the course of Parkinson's disease (PD). However, these have lacked either anatomic definition or the ability to recognize minute changes in BBB integrity. Here, using histologic markers of serum protein, iron,...

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Bibliographic Details
Published in:Journal of cerebral blood flow and metabolism 2015-05, Vol.35 (5), p.747-750
Main Authors: Gray, Madison T, Woulfe, John M
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Biomarkers - metabolism
Blood Proteins - metabolism
Blood-Brain Barrier - metabolism
Blood-Brain Barrier - pathology
Brief Communication
Capillary Permeability
Erythrocytes - metabolism
Erythrocytes - pathology
Female
Humans
Iron - metabolism
Male
Middle Aged
Parkinson Disease - metabolism
Parkinson Disease - pathology
Parkinson's disease
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Summary:In vivo studies have shown that blood–brain barrier (BBB) dysfunction is involved in the course of Parkinson's disease (PD). However, these have lacked either anatomic definition or the ability to recognize minute changes in BBB integrity. Here, using histologic markers of serum protein, iron, and erythrocyte extravasation, we have shown significantly increased permeability of the BBB in the postcommissural putamen of PD patients. The dense innervation of the striatum by PD-affected regions allows for exploitation of this permeability for therapeutic goals. These results are also discussed in the context of the retrograde trans-synaptic hypothesis of PD spread.
ISSN:0271-678X
1559-7016
DOI:10.1038/jcbfm.2015.32