Design, synthesis and antibacterial potential of 5-(benzo[d][1,3]dioxol-5-yl)-3-tert-butyl-1-substituted-4,5-dihydropyrazoles

A series of 5-(benzo[d][1,3]dioxol-5-yl)-3-tert-butyl-1-substituted-4,5-dihydropyrazole derivatives 4a–e and 6a–g have been synthesized and spectrally characterized. The antibacterial activity of the novel candidates has been screened using the agar diffusion test. These compounds were endowed with...

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Bibliographic Details
Published in:Saudi pharmaceutical journal 2015-04, Vol.23 (2), p.202-209
Main Authors: El-Behairy, Mohammed F., Mazeed, Tarek E., El-Azzouny, Aida A., Aboul-Enein, Mohamed N.
Format: Article
Language:English
Subjects:
1,3-Benzodioxole
2-Pyrazoline
Antibacterial
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Summary:A series of 5-(benzo[d][1,3]dioxol-5-yl)-3-tert-butyl-1-substituted-4,5-dihydropyrazole derivatives 4a–e and 6a–g have been synthesized and spectrally characterized. The antibacterial activity of the novel candidates has been screened using the agar diffusion test. These compounds were endowed with high antibacterial activity against different Gram +ve and Gram −ve bacteria when compared with standard antibacterial drugs. In the light of zone of inhibition and MIC results, Sarcina and Staphylococcus aureus are the most sensitive bacteria where pyrrolidinomethanone derivative 4e showed MICs at 80 and 110nM, respectively. While hydroxypiperidinoethanone derivative 6c showed MIC at 90nM for Sarcina.
ISSN:1319-0164
2213-7475
DOI:10.1016/j.jsps.2014.07.009