Clinical effects of icodextrin in peritoneal dialysis

Objective. This study reviews the relevant publications on the clinical effects of icodextrin in peritoneal dialysis (PD). Design. The study provides a systematic review of the literature (MEDLINE search with icodextrin as the keyword). Results. Icodextrin induces sustained transcapillary ultrafiltr...

Full description

Saved in:
Bibliographic Details
Published in:Clinical kidney journal 2008-10, Vol.1 (suppl_4), p.iv18-iv22
Main Authors: Cnossen, Trijntje T., Konings, Constantijn J., van der Sande, Frank M., Leunissen, Karel M., Kooman, Jeroen P.
Format: Article
Language:English
Subjects:
Original
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objective. This study reviews the relevant publications on the clinical effects of icodextrin in peritoneal dialysis (PD). Design. The study provides a systematic review of the literature (MEDLINE search with icodextrin as the keyword). Results. Icodextrin induces sustained transcapillary ultrafiltration during long dwell periods. It also stimulates increased removal of sodium by the peritoneal membrane, reduction of extracellular water (ECW) and total body water (TBW). Effects of icodextrin on blood pressure control and residual renal function are discrepant. Icodextrin induces a reduction in the formation of advanced glycation end-products, while the longitudinal changes in the peritoneal membrane transport are less prominent. Conclusions. Use of icodextrin in PD improves the sodium and fluid balance. Icodextrin is potentially more biocompatible, when compared with the conventional glucose solutions. The side effects are rare.
ISSN:2048-8505
1753-0784
2048-8513
1753-0792
DOI:10.1093/ndtplus/sfn119