Abrupt and durable remission of Henoch–Schönlein purpura nephritis with cyclosporine A

Henoch–Schönlein purpura glomerulonephritis (HSP-GN) is a common form of systemic small vessel vasculitis in children. Although prognosis is usually favourable, the disease is occasionally associated with a risk of renal insufficiency. Various immunosuppressive agents have been used in patients with...

Full description

Saved in:
Bibliographic Details
Published in:Clinical kidney journal 2008-10, Vol.1 (5), p.300-302
Main Authors: Georgaki-Angelaki, Eleni, Kostaridou, Stavroula, Lourida, Athanasia, Petraki, C., Lagona, Evagelia
Format: Article
Language:English
Subjects:
Case Report
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Henoch–Schönlein purpura glomerulonephritis (HSP-GN) is a common form of systemic small vessel vasculitis in children. Although prognosis is usually favourable, the disease is occasionally associated with a risk of renal insufficiency. Various immunosuppressive agents have been used in patients with severe HSP-GN, but none have shown convincing favourable effects. We report a case of biopsy-proven HSP-related GN in a 4-year-old girl that responded remarkably well to cyclosporine A (CsA), following failure to respond to other immunosuppressive agents. At 8 months post-CsA treatment, repeat renal biopsy findings were consistent with histological improvement. We conclude that CsA treatment not only exerts beneficial effects on resistant HSP-related GN but may also arrest progression of the disease.
ISSN:2048-8505
1753-0784
2048-8513
1753-0792
DOI:10.1093/ndtplus/sfn105