Post-transplant lymphoproliferative disorder: case report and review of susceptibility to EBV in the Scottish adult renal transplant pool

We report a case of high-grade non-Hodgkin's lymphoma following Epstein-Barr virus (EBV) infection in a 38-year-old renal transplant recipient who was successfully treated with rituximab and remains alive 6 years later with reasonable graft function. We subsequently undertook a survey showing t...

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Bibliographic Details
Published in:Clinical kidney journal 2009-02, Vol.2 (1), p.52-54
Main Authors: Selvarajah, Viknesh, Lake, Katie, Robertson, Sue, Carman, William, Isles, Chris
Format: Article
Language:English
Subjects:
Case Report
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Summary:We report a case of high-grade non-Hodgkin's lymphoma following Epstein-Barr virus (EBV) infection in a 38-year-old renal transplant recipient who was successfully treated with rituximab and remains alive 6 years later with reasonable graft function. We subsequently undertook a survey showing that 1.8% of the Scottish adult transplant pool are susceptible to EBV infection. Though a vaccine for EBV is currently not yet available, routine screening of potential renal transplant recipients for EBV should help identify those at increased risk of post-transplant lymhoproliferative disorder (PTLD), while tailoring of immunosuppression and antiviral prophylaxis with Ganciclovir may help reduce the emergence of this potentially life-threatening disease.
ISSN:2048-8505
1753-0784
2048-8513
1753-0792
DOI:10.1093/ndtplus/sfn180