Obesity susceptibility loci in Qataris, a highly consanguineous Arabian population

In Qataris, a population characterized by a small size and a high rate of consanguinity, between two-thirds to three-quarters of adults are overweight or obese. We investigated the relevance of 23 obesity-related loci in the Qatari population. Eight-hundred-four individuals assessed to be third gene...

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Bibliographic Details
Published in:Journal of translational medicine 2015-04, Vol.13 (1), p.119-119, Article 119
Main Authors: Tomei, Sara, Mamtani, Ravinder, Al Ali, Rashid, Elkum, Naser, Abdulmalik, Maryam, Ismail, Awatef, Cheema, Sohaila, Rouh, Hekmat A, Aigha, Idil I, Hani, Fatima, Al-Samraye, Sura, Taher Aseel, Mona, El Emadi, Nada, Al Mujalli, Azza, Abdelkerim, Ahmed, Youssif, Siddik, Worschech, Andrea, El Sebakhy, Emad, Temanni, Ramzi, Khanna, Vineesh, Wang, Ena, Kizhakayil, Dhanya, Al-Thani, Al-Anood, Al-Thani, Mohammed, Lowenfels, Albert, Marincola, Francesco M, Sheikh, Javaid, Chouchane, Lotfi
Format: Article
Language:English
Subjects:
Adult
Arabs - genetics
Body Mass Index
Consanguinity
Continental Population Groups - genetics
Female
Genetic Loci
Genetic Predisposition to Disease
Humans
Logistic Models
Male
Middle Aged
Obesity - genetics
Phenotype
Polymorphism, Single Nucleotide - genetics
Principal Component Analysis
Qatar
Thinness - genetics
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Summary:In Qataris, a population characterized by a small size and a high rate of consanguinity, between two-thirds to three-quarters of adults are overweight or obese. We investigated the relevance of 23 obesity-related loci in the Qatari population. Eight-hundred-four individuals assessed to be third generation Qataris were included in the study and assigned to 3 groups according to their body mass index (BMI): 190 lean (BMI 
ISSN:1479-5876
1479-5876
DOI:10.1186/s12967-015-0459-3