Synthesis and bioactivities of silver nanoparticles capped with 5-Amino-?-resorcylic acid hydrochloride dihydrate

Conjugated and drug loaded silver nanoparticles are getting an increased attention for various biomedical applications. Nanoconjugates showed significant enhancement in biological activity in comparison to free drug molecules. In this perspective, we report the synthesis of bioactive silver capped w...

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Bibliographic Details
Published in:Journal of nanobiotechnology 2014-09, Vol.12 (1), p.34-34, Article 34
Main Authors: Naz, Syeda Sohaila, Shah, Muhammad Raza, Islam, Nazar Ul, Khan, Ajmal, Nazir, Samina, Qaisar, Sara, Alam, Syed Sartaj
Format: Article
Language:English
Subjects:
Acids
Aqueous solutions
Biomedical engineering
Chymotrypsin
Colleges & universities
Conjugation
Drugs
Enzymes
Gold
Inhibition
Inhibitors
Methods
Nanoparticles
Nanostructure
Physics
Physiological aspects
Silver
Spectrum analysis
Xanthines
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Summary:Conjugated and drug loaded silver nanoparticles are getting an increased attention for various biomedical applications. Nanoconjugates showed significant enhancement in biological activity in comparison to free drug molecules. In this perspective, we report the synthesis of bioactive silver capped with 5-Amino-?-resorcylic acid hydrochloride dihydrate (AR). The in vitro antimicrobial (antibacterial, antifungal), enzyme inhibition (xanthine oxidase, urease, carbonic anhydrase, ?-chymotrypsin, cholinesterase) and antioxidant activities of the developed nanostructures was investigated before and after conjugation to silver metal. The conjugation of AR to silver was confirmed through FTIR, UV-vis and TEM techniques. The amount of AR conjugated with silver was characterized through UV-vis spectroscopy and found to be 9% by weight. The stability of synthesized nanoconjugates against temperature, high salt concentration and pH was found to be good. Nanoconjugates, showed significant synergic enzyme inhibition effect against xanthine and urease enzymes in comparison to standard drugs, pure ligand and silver. Our synthesized nanoconjugate was found be to efficient selective xanthine and urease inhibitors in comparison to Ag and AR. On a per weight basis, our nanoconjugates required less amount of AR (about 11 times) for inhibition of these enzymes.
ISSN:1477-3155
1477-3155
DOI:10.1186/s12951-014-0034-8