Phenotypic heterogeneity of latent autoimmune diabetes in adults identified by body composition analysis

In patients with Latent Autoimmune Diabetes in Adults (LADA) a lower body mass index was reported compared with classical type 2 diabetes (T2D), and was found to be associated with a faster progression to insulin-dependence. In this study we determined the body composition in a cohort of LADA patien...

Full description

Saved in:
Bibliographic Details
Published in:Diabetology and metabolic syndrome 2014-11, Vol.6 (1), p.128-128, Article 128
Main Authors: Pes, Giovanni Mario, Delitala, Alessandro Palmerio, Delitala, Giuseppe, Errigo, Alessandra, Costantino, Salvatore, Fanciulli, Giuseppe
Format: Article
Language:English
Subjects:
Age
Body mass index
Comparative analysis
Diabetes
Health aspects
Insulin
Medical research
Medicine, Experimental
Metabolism
Physiological aspects
Studies
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In patients with Latent Autoimmune Diabetes in Adults (LADA) a lower body mass index was reported compared with classical type 2 diabetes (T2D), and was found to be associated with a faster progression to insulin-dependence. In this study we determined the body composition in a cohort of LADA patients from Sardinia, Italy, and compared it with age- and gender-matched patients diagnosed as having adult-onset type 1 diabetes (T1D) and non-autoimmune T2D. In 210 LADA patients, 210 T2D patients and 30 adult-onset T1D patients of Sardinian origin we assessed total and segmental body composition (weight-adjusted percent fat mass and lean mass) by using Dual Energy X-rays Absorptiometry (DXA). In the whole cohort of LADA patients total fat mass was significantly smaller compared with T2D patients (p 
ISSN:1758-5996
1758-5996
DOI:10.1186/1758-5996-6-128