Advances and Challenges in Immunotherapy for Solid Organ and Bone Marrow Transplantation

Although major advances have been made in hematopoietic stem cell transplantation (HSCT) and solid organ transplantation in the last 50 years, big challenges remain. This Review outlines the current immunological limitations for HSCT and solid organ transplantation, and discusses new immune-modulati...

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Bibliographic Details
Published in:Science translational medicine 2015-03, Vol.7 (280), p.280rv2-280rv2
Main Authors: McDonald-Hyman, Cameron, Turka, Laurence A., Blazar, Bruce R.
Format: Article
Language:English
Online Access:Get full text
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Summary:Although major advances have been made in hematopoietic stem cell transplantation (HSCT) and solid organ transplantation in the last 50 years, big challenges remain. This Review outlines the current immunological limitations for HSCT and solid organ transplantation, and discusses new immune-modulating therapies in clinical trials and under pre-clinical development that may allow these obstacles to be overcome.
ISSN:1946-6234
1946-6242
DOI:10.1126/scitranslmed.aaa6853