Loading…
Adiponectin and interleukin-6, but not adipose tissue, are associated with worse neurocognitive function in HIV-infected men
Generalized obesity has been associated with cognitive decline, a process potentially mediated by adipocytokines. The effects of regional adipose tissue (AT) on cognition, however, are not well understood. We explored cross-sectional relationships between regional AT, adipocytokines, inflammatory ma...
Saved in:
| Published in: | Antiviral therapy 2015-01, Vol.20 (2), p.235-244 |
|---|---|
| Main Authors: | , , , , , , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c402t-4e04bd4616371c22e4ab5d6493c6458beb7c5f061a0f755a77c35115e24ec8683 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c402t-4e04bd4616371c22e4ab5d6493c6458beb7c5f061a0f755a77c35115e24ec8683 |
| container_end_page | 244 |
| container_issue | 2 |
| container_start_page | 235 |
| container_title | Antiviral therapy |
| container_volume | 20 |
| creator | Lake, Jordan E Vo, Quynh T Jacobson, Lisa P Sacktor, Ned Miller, Eric N Post, Wendy S Becker, James T Palella, Jr, Frank J Ragin, Ann Martin, Eileen Munro, Cynthia A Brown, Todd T |
| description | Generalized obesity has been associated with cognitive decline, a process potentially mediated by adipocytokines. The effects of regional adipose tissue (AT) on cognition, however, are not well understood. We explored cross-sectional relationships between regional AT, adipocytokines, inflammatory markers and neuropsychological (NP) test scores among HIV+ and HIV- men enrolled in the Multicenter AIDS Cohort Study.
Visceral, subcutaneous abdominal and subcutaneous thigh AT areas were quantified by computed tomography (CT). NP tests (Trail Making Test parts A and B, and Symbol-Digit Modalities) obtained within 2 years of CT screened for psychomotor speed and executive function. Adiponectin, leptin, interleukin-6 (IL-6) and high-sensitivity C-reactive protein (hs-CRP) were measured.
Of 509 HIV+ and 271 HIV- participants, HIV+ men (98% on antiretroviral therapy, 81% HIV-1 RNA |
| doi_str_mv | 10.3851/IMP2952 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4425574</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1855079735</sourcerecordid><originalsourceid>FETCH-LOGICAL-c402t-4e04bd4616371c22e4ab5d6493c6458beb7c5f061a0f755a77c35115e24ec8683</originalsourceid><addsrcrecordid>eNqFkU1v1DAQhi0EosuC-AfIN3poWn9N7FyQqgroSkXlAFwtx5m0hqy92E6rSvx4UnWp4MRpDvPMMzN6CXnN2bE0wE82nz6LDsQTshJMsUYwME_JikvomhYkHJAXpXxnTJiOsefkQIDhTGq9Ir9Oh7BLEX0Nkbo40BAr5gnnHyE27RHt50pjqtTdYwVpDaXMeERdRupKST64igO9DfWa3qa8EBHnnHy6iqGGG6TjHBd3iouYnm--NSGOy7JlZIvxJXk2uqngq31dk68f3n85O28uLj9uzk4vGq-YqI1CpvpBtbyVmnshULkehlZ10rcKTI-99jCyljs2agCntZfAOaBQ6E1r5Jq8e_Du5n6Lg8dYs5vsLoety3c2uWD_7cRwba_SjVVKAGi1CA73gpx-zliq3YbicZpcxDQXyw0A052W8H-0NYxrw5fr1-TtA-pzKiXj-HgRZ_Y-VruPdSHf_P3AI_cnR_kbr6uekw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1680178149</pqid></control><display><type>article</type><title>Adiponectin and interleukin-6, but not adipose tissue, are associated with worse neurocognitive function in HIV-infected men</title><source>Sage Journals GOLD Open Access 2024</source><creator>Lake, Jordan E ; Vo, Quynh T ; Jacobson, Lisa P ; Sacktor, Ned ; Miller, Eric N ; Post, Wendy S ; Becker, James T ; Palella, Jr, Frank J ; Ragin, Ann ; Martin, Eileen ; Munro, Cynthia A ; Brown, Todd T</creator><creatorcontrib>Lake, Jordan E ; Vo, Quynh T ; Jacobson, Lisa P ; Sacktor, Ned ; Miller, Eric N ; Post, Wendy S ; Becker, James T ; Palella, Jr, Frank J ; Ragin, Ann ; Martin, Eileen ; Munro, Cynthia A ; Brown, Todd T</creatorcontrib><description>Generalized obesity has been associated with cognitive decline, a process potentially mediated by adipocytokines. The effects of regional adipose tissue (AT) on cognition, however, are not well understood. We explored cross-sectional relationships between regional AT, adipocytokines, inflammatory markers and neuropsychological (NP) test scores among HIV+ and HIV- men enrolled in the Multicenter AIDS Cohort Study.
Visceral, subcutaneous abdominal and subcutaneous thigh AT areas were quantified by computed tomography (CT). NP tests (Trail Making Test parts A and B, and Symbol-Digit Modalities) obtained within 2 years of CT screened for psychomotor speed and executive function. Adiponectin, leptin, interleukin-6 (IL-6) and high-sensitivity C-reactive protein (hs-CRP) were measured.
Of 509 HIV+ and 271 HIV- participants, HIV+ men (98% on antiretroviral therapy, 81% HIV-1 RNA<50 copies/ml) had lower median subcutaneous AT and adiponectin levels and higher hs-CRP levels, but visceral AT, body mass index, IL-6 and NP scores did not vary by HIV serostatus. In multivariable analysis, older age, ≤ high school education and African American race, but not AT area or site, were associated with worse NP test scores among all participants. In HIV+ only, higher adiponectin and IL-6 were associated with worse cognitive function independent of AT area. No HIV-specific factors were associated with NP test scores.
Demographic factors were associated with NP test performance, but regional adiposity was not. In HIV+ only, higher adiponectin and IL-6 were associated with worse NP test scores, supporting a role for chronic inflammation and adipocytokine imbalance in neurocognitive decline in HIV+ persons.</description><identifier>ISSN: 1359-6535</identifier><identifier>EISSN: 2040-2058</identifier><identifier>DOI: 10.3851/IMP2952</identifier><identifier>PMID: 25810377</identifier><language>eng</language><publisher>England</publisher><subject>Adiponectin - blood ; Adipose Tissue - pathology ; Adipose Tissue - virology ; Age Factors ; Anti-HIV Agents - therapeutic use ; Antiretroviral Therapy, Highly Active ; Biomarkers - blood ; C-Reactive Protein - metabolism ; Cognitive Dysfunction - complications ; Cognitive Dysfunction - drug therapy ; Cognitive Dysfunction - psychology ; Cognitive Dysfunction - virology ; Cohort Studies ; Disease Progression ; Educational Status ; Executive Function ; HIV Infections - complications ; HIV Infections - drug therapy ; HIV Infections - psychology ; HIV Infections - virology ; HIV-1 - drug effects ; HIV-1 - physiology ; Humans ; Interleukin-6 - blood ; Lentivirus ; Leptin - blood ; Male ; Middle Aged ; Multivariate Analysis ; Neuropsychological Tests ; Obesity - complications ; Obesity - drug therapy ; Obesity - psychology ; Obesity - virology ; Psychomotor Performance ; Retroviridae ; RNA, Viral - antagonists & inhibitors ; RNA, Viral - blood ; Viral Load - drug effects</subject><ispartof>Antiviral therapy, 2015-01, Vol.20 (2), p.235-244</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c402t-4e04bd4616371c22e4ab5d6493c6458beb7c5f061a0f755a77c35115e24ec8683</citedby><cites>FETCH-LOGICAL-c402t-4e04bd4616371c22e4ab5d6493c6458beb7c5f061a0f755a77c35115e24ec8683</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27915,27916</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25810377$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lake, Jordan E</creatorcontrib><creatorcontrib>Vo, Quynh T</creatorcontrib><creatorcontrib>Jacobson, Lisa P</creatorcontrib><creatorcontrib>Sacktor, Ned</creatorcontrib><creatorcontrib>Miller, Eric N</creatorcontrib><creatorcontrib>Post, Wendy S</creatorcontrib><creatorcontrib>Becker, James T</creatorcontrib><creatorcontrib>Palella, Jr, Frank J</creatorcontrib><creatorcontrib>Ragin, Ann</creatorcontrib><creatorcontrib>Martin, Eileen</creatorcontrib><creatorcontrib>Munro, Cynthia A</creatorcontrib><creatorcontrib>Brown, Todd T</creatorcontrib><title>Adiponectin and interleukin-6, but not adipose tissue, are associated with worse neurocognitive function in HIV-infected men</title><title>Antiviral therapy</title><addtitle>Antivir Ther</addtitle><description>Generalized obesity has been associated with cognitive decline, a process potentially mediated by adipocytokines. The effects of regional adipose tissue (AT) on cognition, however, are not well understood. We explored cross-sectional relationships between regional AT, adipocytokines, inflammatory markers and neuropsychological (NP) test scores among HIV+ and HIV- men enrolled in the Multicenter AIDS Cohort Study.
Visceral, subcutaneous abdominal and subcutaneous thigh AT areas were quantified by computed tomography (CT). NP tests (Trail Making Test parts A and B, and Symbol-Digit Modalities) obtained within 2 years of CT screened for psychomotor speed and executive function. Adiponectin, leptin, interleukin-6 (IL-6) and high-sensitivity C-reactive protein (hs-CRP) were measured.
Of 509 HIV+ and 271 HIV- participants, HIV+ men (98% on antiretroviral therapy, 81% HIV-1 RNA<50 copies/ml) had lower median subcutaneous AT and adiponectin levels and higher hs-CRP levels, but visceral AT, body mass index, IL-6 and NP scores did not vary by HIV serostatus. In multivariable analysis, older age, ≤ high school education and African American race, but not AT area or site, were associated with worse NP test scores among all participants. In HIV+ only, higher adiponectin and IL-6 were associated with worse cognitive function independent of AT area. No HIV-specific factors were associated with NP test scores.
Demographic factors were associated with NP test performance, but regional adiposity was not. In HIV+ only, higher adiponectin and IL-6 were associated with worse NP test scores, supporting a role for chronic inflammation and adipocytokine imbalance in neurocognitive decline in HIV+ persons.</description><subject>Adiponectin - blood</subject><subject>Adipose Tissue - pathology</subject><subject>Adipose Tissue - virology</subject><subject>Age Factors</subject><subject>Anti-HIV Agents - therapeutic use</subject><subject>Antiretroviral Therapy, Highly Active</subject><subject>Biomarkers - blood</subject><subject>C-Reactive Protein - metabolism</subject><subject>Cognitive Dysfunction - complications</subject><subject>Cognitive Dysfunction - drug therapy</subject><subject>Cognitive Dysfunction - psychology</subject><subject>Cognitive Dysfunction - virology</subject><subject>Cohort Studies</subject><subject>Disease Progression</subject><subject>Educational Status</subject><subject>Executive Function</subject><subject>HIV Infections - complications</subject><subject>HIV Infections - drug therapy</subject><subject>HIV Infections - psychology</subject><subject>HIV Infections - virology</subject><subject>HIV-1 - drug effects</subject><subject>HIV-1 - physiology</subject><subject>Humans</subject><subject>Interleukin-6 - blood</subject><subject>Lentivirus</subject><subject>Leptin - blood</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Neuropsychological Tests</subject><subject>Obesity - complications</subject><subject>Obesity - drug therapy</subject><subject>Obesity - psychology</subject><subject>Obesity - virology</subject><subject>Psychomotor Performance</subject><subject>Retroviridae</subject><subject>RNA, Viral - antagonists & inhibitors</subject><subject>RNA, Viral - blood</subject><subject>Viral Load - drug effects</subject><issn>1359-6535</issn><issn>2040-2058</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNqFkU1v1DAQhi0EosuC-AfIN3poWn9N7FyQqgroSkXlAFwtx5m0hqy92E6rSvx4UnWp4MRpDvPMMzN6CXnN2bE0wE82nz6LDsQTshJMsUYwME_JikvomhYkHJAXpXxnTJiOsefkQIDhTGq9Ir9Oh7BLEX0Nkbo40BAr5gnnHyE27RHt50pjqtTdYwVpDaXMeERdRupKST64igO9DfWa3qa8EBHnnHy6iqGGG6TjHBd3iouYnm--NSGOy7JlZIvxJXk2uqngq31dk68f3n85O28uLj9uzk4vGq-YqI1CpvpBtbyVmnshULkehlZ10rcKTI-99jCyljs2agCntZfAOaBQ6E1r5Jq8e_Du5n6Lg8dYs5vsLoety3c2uWD_7cRwba_SjVVKAGi1CA73gpx-zliq3YbicZpcxDQXyw0A052W8H-0NYxrw5fr1-TtA-pzKiXj-HgRZ_Y-VruPdSHf_P3AI_cnR_kbr6uekw</recordid><startdate>20150101</startdate><enddate>20150101</enddate><creator>Lake, Jordan E</creator><creator>Vo, Quynh T</creator><creator>Jacobson, Lisa P</creator><creator>Sacktor, Ned</creator><creator>Miller, Eric N</creator><creator>Post, Wendy S</creator><creator>Becker, James T</creator><creator>Palella, Jr, Frank J</creator><creator>Ragin, Ann</creator><creator>Martin, Eileen</creator><creator>Munro, Cynthia A</creator><creator>Brown, Todd T</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7U9</scope><scope>H94</scope><scope>5PM</scope></search><sort><creationdate>20150101</creationdate><title>Adiponectin and interleukin-6, but not adipose tissue, are associated with worse neurocognitive function in HIV-infected men</title><author>Lake, Jordan E ; Vo, Quynh T ; Jacobson, Lisa P ; Sacktor, Ned ; Miller, Eric N ; Post, Wendy S ; Becker, James T ; Palella, Jr, Frank J ; Ragin, Ann ; Martin, Eileen ; Munro, Cynthia A ; Brown, Todd T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c402t-4e04bd4616371c22e4ab5d6493c6458beb7c5f061a0f755a77c35115e24ec8683</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adiponectin - blood</topic><topic>Adipose Tissue - pathology</topic><topic>Adipose Tissue - virology</topic><topic>Age Factors</topic><topic>Anti-HIV Agents - therapeutic use</topic><topic>Antiretroviral Therapy, Highly Active</topic><topic>Biomarkers - blood</topic><topic>C-Reactive Protein - metabolism</topic><topic>Cognitive Dysfunction - complications</topic><topic>Cognitive Dysfunction - drug therapy</topic><topic>Cognitive Dysfunction - psychology</topic><topic>Cognitive Dysfunction - virology</topic><topic>Cohort Studies</topic><topic>Disease Progression</topic><topic>Educational Status</topic><topic>Executive Function</topic><topic>HIV Infections - complications</topic><topic>HIV Infections - drug therapy</topic><topic>HIV Infections - psychology</topic><topic>HIV Infections - virology</topic><topic>HIV-1 - drug effects</topic><topic>HIV-1 - physiology</topic><topic>Humans</topic><topic>Interleukin-6 - blood</topic><topic>Lentivirus</topic><topic>Leptin - blood</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Neuropsychological Tests</topic><topic>Obesity - complications</topic><topic>Obesity - drug therapy</topic><topic>Obesity - psychology</topic><topic>Obesity - virology</topic><topic>Psychomotor Performance</topic><topic>Retroviridae</topic><topic>RNA, Viral - antagonists & inhibitors</topic><topic>RNA, Viral - blood</topic><topic>Viral Load - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lake, Jordan E</creatorcontrib><creatorcontrib>Vo, Quynh T</creatorcontrib><creatorcontrib>Jacobson, Lisa P</creatorcontrib><creatorcontrib>Sacktor, Ned</creatorcontrib><creatorcontrib>Miller, Eric N</creatorcontrib><creatorcontrib>Post, Wendy S</creatorcontrib><creatorcontrib>Becker, James T</creatorcontrib><creatorcontrib>Palella, Jr, Frank J</creatorcontrib><creatorcontrib>Ragin, Ann</creatorcontrib><creatorcontrib>Martin, Eileen</creatorcontrib><creatorcontrib>Munro, Cynthia A</creatorcontrib><creatorcontrib>Brown, Todd T</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Antiviral therapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lake, Jordan E</au><au>Vo, Quynh T</au><au>Jacobson, Lisa P</au><au>Sacktor, Ned</au><au>Miller, Eric N</au><au>Post, Wendy S</au><au>Becker, James T</au><au>Palella, Jr, Frank J</au><au>Ragin, Ann</au><au>Martin, Eileen</au><au>Munro, Cynthia A</au><au>Brown, Todd T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Adiponectin and interleukin-6, but not adipose tissue, are associated with worse neurocognitive function in HIV-infected men</atitle><jtitle>Antiviral therapy</jtitle><addtitle>Antivir Ther</addtitle><date>2015-01-01</date><risdate>2015</risdate><volume>20</volume><issue>2</issue><spage>235</spage><epage>244</epage><pages>235-244</pages><issn>1359-6535</issn><eissn>2040-2058</eissn><abstract>Generalized obesity has been associated with cognitive decline, a process potentially mediated by adipocytokines. The effects of regional adipose tissue (AT) on cognition, however, are not well understood. We explored cross-sectional relationships between regional AT, adipocytokines, inflammatory markers and neuropsychological (NP) test scores among HIV+ and HIV- men enrolled in the Multicenter AIDS Cohort Study.
Visceral, subcutaneous abdominal and subcutaneous thigh AT areas were quantified by computed tomography (CT). NP tests (Trail Making Test parts A and B, and Symbol-Digit Modalities) obtained within 2 years of CT screened for psychomotor speed and executive function. Adiponectin, leptin, interleukin-6 (IL-6) and high-sensitivity C-reactive protein (hs-CRP) were measured.
Of 509 HIV+ and 271 HIV- participants, HIV+ men (98% on antiretroviral therapy, 81% HIV-1 RNA<50 copies/ml) had lower median subcutaneous AT and adiponectin levels and higher hs-CRP levels, but visceral AT, body mass index, IL-6 and NP scores did not vary by HIV serostatus. In multivariable analysis, older age, ≤ high school education and African American race, but not AT area or site, were associated with worse NP test scores among all participants. In HIV+ only, higher adiponectin and IL-6 were associated with worse cognitive function independent of AT area. No HIV-specific factors were associated with NP test scores.
Demographic factors were associated with NP test performance, but regional adiposity was not. In HIV+ only, higher adiponectin and IL-6 were associated with worse NP test scores, supporting a role for chronic inflammation and adipocytokine imbalance in neurocognitive decline in HIV+ persons.</abstract><cop>England</cop><pmid>25810377</pmid><doi>10.3851/IMP2952</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1359-6535 |
| ispartof | Antiviral therapy, 2015-01, Vol.20 (2), p.235-244 |
| issn | 1359-6535 2040-2058 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4425574 |
| source | Sage Journals GOLD Open Access 2024 |
| subjects | Adiponectin - blood Adipose Tissue - pathology Adipose Tissue - virology Age Factors Anti-HIV Agents - therapeutic use Antiretroviral Therapy, Highly Active Biomarkers - blood C-Reactive Protein - metabolism Cognitive Dysfunction - complications Cognitive Dysfunction - drug therapy Cognitive Dysfunction - psychology Cognitive Dysfunction - virology Cohort Studies Disease Progression Educational Status Executive Function HIV Infections - complications HIV Infections - drug therapy HIV Infections - psychology HIV Infections - virology HIV-1 - drug effects HIV-1 - physiology Humans Interleukin-6 - blood Lentivirus Leptin - blood Male Middle Aged Multivariate Analysis Neuropsychological Tests Obesity - complications Obesity - drug therapy Obesity - psychology Obesity - virology Psychomotor Performance Retroviridae RNA, Viral - antagonists & inhibitors RNA, Viral - blood Viral Load - drug effects |
| title | Adiponectin and interleukin-6, but not adipose tissue, are associated with worse neurocognitive function in HIV-infected men |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-15T05%3A45%3A43IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Adiponectin%20and%20interleukin-6,%20but%20not%20adipose%20tissue,%20are%20associated%20with%20worse%20neurocognitive%20function%20in%20HIV-infected%20men&rft.jtitle=Antiviral%20therapy&rft.au=Lake,%20Jordan%20E&rft.date=2015-01-01&rft.volume=20&rft.issue=2&rft.spage=235&rft.epage=244&rft.pages=235-244&rft.issn=1359-6535&rft.eissn=2040-2058&rft_id=info:doi/10.3851/IMP2952&rft_dat=%3Cproquest_pubme%3E1855079735%3C/proquest_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c402t-4e04bd4616371c22e4ab5d6493c6458beb7c5f061a0f755a77c35115e24ec8683%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1680178149&rft_id=info:pmid/25810377&rfr_iscdi=true |