Targets of drugs are generally and targets of drugs having side effects are specifically good spreaders of human interactome perturbations

Network-based methods are playing an increasingly important role in drug design. Our main question in this paper was whether the efficiency of drug target proteins to spread perturbations in the human interactome is larger if the binding drugs have side effects, as compared to those which have no re...

Full description

Saved in:
Bibliographic Details
Published in:Scientific reports 2015-05, Vol.5 (1), p.10182-10182, Article 10182
Main Authors: Perez-Lopez, Áron R., Szalay, Kristóf Z., Türei, Dénes, Módos, Dezső, Lenti, Katalin, Korcsmáros, Tamás, Csermely, Peter
Format: Article
Language:English
Subjects:
631/114
639/705/1042
Colorectal cancer
Colorectal carcinoma
Colorectal Neoplasms - metabolism
Diabetes
Diabetes mellitus
Diabetes Mellitus, Type 2 - metabolism
Drug Delivery Systems
Drug development
Drug-Related Side Effects and Adverse Reactions - metabolism
Drugs
Humanities and Social Sciences
Humans
multidisciplinary
Neoplasm Proteins - metabolism
Protein interaction
Protein Interaction Maps
Proteins
Science
Side effects
Time Factors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Network-based methods are playing an increasingly important role in drug design. Our main question in this paper was whether the efficiency of drug target proteins to spread perturbations in the human interactome is larger if the binding drugs have side effects, as compared to those which have no reported side effects. Our results showed that in general, drug targets were better spreaders of perturbations than non-target proteins and in particular, targets of drugs with side effects were also better spreaders of perturbations than targets of drugs having no reported side effects in human protein-protein interaction networks. Colorectal cancer-related proteins were good spreaders and had a high centrality, while type 2 diabetes-related proteins showed an average spreading efficiency and had an average centrality in the human interactome. Moreover, the interactome-distance between drug targets and disease-related proteins was higher in diabetes than in colorectal cancer. Our results may help a better understanding of the network position and dynamics of drug targets and disease-related proteins and may contribute to develop additional, network-based tests to increase the potential safety of drug candidates.
ISSN:2045-2322
2045-2322
DOI:10.1038/srep10182