Phylogeny from Function: Evidence from the Molecular Fossil Record that tRNA Originated in Replication, not Translation

We propose a phylogeny for the evolution of tRNA that is based on the ubiquity and conservation of tRNA-like structures in the replication of contemporary genomes. This phylogeny is unique in suggesting that the function of tRNA in replication dates back to the very beginnings of life on earth, befo...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1994-07, Vol.91 (15), p.6729-6734
Main Authors: Maizels, Nancy, Weiner, Alan M.
Format: Article
Language:English
Subjects:
Animals
Anticodon
Conserved Sequence
DNA
DNA Replication
Enzymes
Evolution
Fossils
Genomes
Genomics
Geological time
Humans
Molecules
Paleontology
Phylogeny
Protein Biosynthesis
Ribonucleic acid
RNA
RNA, Transfer - genetics
RNA, Transfer - metabolism
Transfer RNA
Viruses
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Summary:We propose a phylogeny for the evolution of tRNA that is based on the ubiquity and conservation of tRNA-like structures in the replication of contemporary genomes. This phylogeny is unique in suggesting that the function of tRNA in replication dates back to the very beginnings of life on earth, before the advent of templated protein synthesis. The origin we propose for tRNA has distinct implications for the order in which other components of the modern translational apparatus evolved. We further suggest that the "top half" of modern tRNA-a coaxial stack of the acceptor stem on the TΨ C arm-is the ancient structural and functional domain and that the "bottom half" of tRNA-a coaxial stack of the dihydrouracil arm on the anticodon arm-arose later to provide additional specificity.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.91.15.6729