Effects of low-dose G-CSF formulation on hematology in healthy horses after long-distance transportation

The present study evaluated the effects of single-dose filgrastim on hematology in 16 healthy horses after long-distance transportation. Horses were assigned to receive filgrastim (0.23 µg/kg, SC, once; G-CSF group; n=8) or saline (0.9% NaCl) solution (0.3 ml, SC, once; control group; n=8) ≤ 1 hr be...

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Published in:Journal of Veterinary Medical Science 2015, Vol.77(4), pp.507-509
Main Authors: ENDO, Yoshiro, HOBO, Seiji, KOROSUE, Kenji, OOTSUKA, Kenji, KITAUCHI, Akira, KIKKAWA, Risa, HIDAKA, Yuichi, HAGIO, Mitsuyoshi, TSUZUKI, Nao
Format: Article
Language:English
Subjects:
Animals
Drug Administration Schedule
Female
filgrastim
Filgrastim - pharmacology
horse
Horses - blood
Internal Medicine
Male
respiratory disease
Time Factors
Transportation
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Summary:The present study evaluated the effects of single-dose filgrastim on hematology in 16 healthy horses after long-distance transportation. Horses were assigned to receive filgrastim (0.23 µg/kg, SC, once; G-CSF group; n=8) or saline (0.9% NaCl) solution (0.3 ml, SC, once; control group; n=8) ≤ 1 hr before transportation. Horses were transported 2,530 km using commercial vans over the course of approximately 44 hr. Clinical examinations and hematologic analyses were performed on all horses before and after transportation. Because the post-transportation white blood cell counts and bacillary neutrophil to segmented neutrophil ratio were significantly higher in the G-CSF group, filgrastim may have promoted the mobilization of neutrophils from marrow. Filgrastim deserves a further study for efficacy in preventing horse shipping fever.
ISSN:0916-7250
1347-7439
DOI:10.1292/jvms.14-0586