Loading…
Inhaled anti-infective chemotherapy for respiratory tract infections: Successes, challenges and the road ahead
One of the most common causes of illnesses in humans is from respiratory tract infections caused by bacterial, viral or fungal pathogens. Inhaled anti-infective drugs are crucial for the prophylaxis and treatment of respiratory tract infections. The benefit of anti-infective drug delivery via inhala...
Saved in:
| Published in: | Advanced drug delivery reviews 2015-05, Vol.85, p.65-82 |
|---|---|
| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c521t-fa02459850b874ad707b43d4422840dc800f2fa13e697ce0cfde65e8fc1e45a43 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c521t-fa02459850b874ad707b43d4422840dc800f2fa13e697ce0cfde65e8fc1e45a43 |
| container_end_page | 82 |
| container_issue | |
| container_start_page | 65 |
| container_title | Advanced drug delivery reviews |
| container_volume | 85 |
| creator | Velkov, Tony Abdul Rahim, Nusaibah Zhou, Qi (Tony) Chan, Hak-Kim Li, Jian |
| description | One of the most common causes of illnesses in humans is from respiratory tract infections caused by bacterial, viral or fungal pathogens. Inhaled anti-infective drugs are crucial for the prophylaxis and treatment of respiratory tract infections. The benefit of anti-infective drug delivery via inhalation is that it affords delivery of sufficient therapeutic dosages directly to the primary site of infection, while minimizing the risks of systemic toxicity or avoiding potential suboptimal pharmacokinetics/pharmacodynamics associated with systemic drug exposure. This review provides an up-to-date treatise of approved and novel developmental inhaled anti-infective agents, with particular attention to effective strategies for their use, pulmonary pharmacokinetic properties and safety.
[Display omitted] |
| doi_str_mv | 10.1016/j.addr.2014.11.004 |
| format | article |
| fullrecord | <record><control><sourceid>elsevier_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4429008</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0169409X14002671</els_id><sourcerecordid>S0169409X14002671</sourcerecordid><originalsourceid>FETCH-LOGICAL-c521t-fa02459850b874ad707b43d4422840dc800f2fa13e697ce0cfde65e8fc1e45a43</originalsourceid><addsrcrecordid>eNp9kM1qGzEUhUVJaVynL5BF0QNkJley5q-UQDBtEjB00Qa6E7J0lZEZS4M0NvjtK-MkNJustNA535E-Qi4ZlAxYfb0plTGx5MBEyVgJID6QGWsbXrS8E2dklkNdIaD7e04-p7QBYLyp4RM555UQNRMwI_7B92pAQ5WfXOG8RT25PVLd4zZMPUY1HqgNkUZMo4tqCvFAp6j0RJ_Dwadv9PdOa0wJ01VuqmFA_4QpMw3NDBqDygM9KnNBPlo1JPzyfM7J488ff5b3xerX3cPydlXoirOpsAq4qLq2gnXbCGUaaNZiYYTgvBVgdAtguVVsgXXXaARtDdYVtlYzFJUSizm5OXHH3XqLRqPPbx7kGN1WxYMMysm3N9718insZZ7oANoM4CeAjiGliPa1y0Ae7cuNPNqXR_uSMZnt59LX_1dfKy-6c-D7KYD573uHUSbt0Gs0LmaX0gT3Hv8fhFOZng</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Inhaled anti-infective chemotherapy for respiratory tract infections: Successes, challenges and the road ahead</title><source>ScienceDirect Freedom Collection</source><creator>Velkov, Tony ; Abdul Rahim, Nusaibah ; Zhou, Qi (Tony) ; Chan, Hak-Kim ; Li, Jian</creator><creatorcontrib>Velkov, Tony ; Abdul Rahim, Nusaibah ; Zhou, Qi (Tony) ; Chan, Hak-Kim ; Li, Jian</creatorcontrib><description>One of the most common causes of illnesses in humans is from respiratory tract infections caused by bacterial, viral or fungal pathogens. Inhaled anti-infective drugs are crucial for the prophylaxis and treatment of respiratory tract infections. The benefit of anti-infective drug delivery via inhalation is that it affords delivery of sufficient therapeutic dosages directly to the primary site of infection, while minimizing the risks of systemic toxicity or avoiding potential suboptimal pharmacokinetics/pharmacodynamics associated with systemic drug exposure. This review provides an up-to-date treatise of approved and novel developmental inhaled anti-infective agents, with particular attention to effective strategies for their use, pulmonary pharmacokinetic properties and safety.
[Display omitted]</description><identifier>ISSN: 0169-409X</identifier><identifier>EISSN: 1872-8294</identifier><identifier>DOI: 10.1016/j.addr.2014.11.004</identifier><identifier>PMID: 25446140</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Administration, Inhalation ; Anti-Bacterial Agents - administration & dosage ; Anti-Bacterial Agents - chemistry ; Anti-Bacterial Agents - therapeutic use ; Antibiotics ; Antifungal Agents - administration & dosage ; Antifungal Agents - chemistry ; Antifungal Agents - therapeutic use ; Antifungals ; Antiviral Agents - administration & dosage ; Antiviral Agents - chemistry ; Antiviral Agents - therapeutic use ; Antivirals ; Clinical Trials as Topic ; Drug Delivery Systems - instrumentation ; Drug Delivery Systems - methods ; Humans ; Inhalation ; Molecular Structure ; Pharmacokinetics/pharmacodynamics ; Respiratory Tract Infections - drug therapy ; Respiratory Tract Infections - microbiology ; Respiratory Tract Infections - virology ; Safety</subject><ispartof>Advanced drug delivery reviews, 2015-05, Vol.85, p.65-82</ispartof><rights>2014 Elsevier B.V.</rights><rights>Copyright © 2014 Elsevier B.V. All rights reserved.</rights><rights>Copyright © 2014 Elsevier B.V. All rights reserved. 2014 Elsevier B.V.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c521t-fa02459850b874ad707b43d4422840dc800f2fa13e697ce0cfde65e8fc1e45a43</citedby><cites>FETCH-LOGICAL-c521t-fa02459850b874ad707b43d4422840dc800f2fa13e697ce0cfde65e8fc1e45a43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25446140$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Velkov, Tony</creatorcontrib><creatorcontrib>Abdul Rahim, Nusaibah</creatorcontrib><creatorcontrib>Zhou, Qi (Tony)</creatorcontrib><creatorcontrib>Chan, Hak-Kim</creatorcontrib><creatorcontrib>Li, Jian</creatorcontrib><title>Inhaled anti-infective chemotherapy for respiratory tract infections: Successes, challenges and the road ahead</title><title>Advanced drug delivery reviews</title><addtitle>Adv Drug Deliv Rev</addtitle><description>One of the most common causes of illnesses in humans is from respiratory tract infections caused by bacterial, viral or fungal pathogens. Inhaled anti-infective drugs are crucial for the prophylaxis and treatment of respiratory tract infections. The benefit of anti-infective drug delivery via inhalation is that it affords delivery of sufficient therapeutic dosages directly to the primary site of infection, while minimizing the risks of systemic toxicity or avoiding potential suboptimal pharmacokinetics/pharmacodynamics associated with systemic drug exposure. This review provides an up-to-date treatise of approved and novel developmental inhaled anti-infective agents, with particular attention to effective strategies for their use, pulmonary pharmacokinetic properties and safety.
[Display omitted]</description><subject>Administration, Inhalation</subject><subject>Anti-Bacterial Agents - administration & dosage</subject><subject>Anti-Bacterial Agents - chemistry</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Antibiotics</subject><subject>Antifungal Agents - administration & dosage</subject><subject>Antifungal Agents - chemistry</subject><subject>Antifungal Agents - therapeutic use</subject><subject>Antifungals</subject><subject>Antiviral Agents - administration & dosage</subject><subject>Antiviral Agents - chemistry</subject><subject>Antiviral Agents - therapeutic use</subject><subject>Antivirals</subject><subject>Clinical Trials as Topic</subject><subject>Drug Delivery Systems - instrumentation</subject><subject>Drug Delivery Systems - methods</subject><subject>Humans</subject><subject>Inhalation</subject><subject>Molecular Structure</subject><subject>Pharmacokinetics/pharmacodynamics</subject><subject>Respiratory Tract Infections - drug therapy</subject><subject>Respiratory Tract Infections - microbiology</subject><subject>Respiratory Tract Infections - virology</subject><subject>Safety</subject><issn>0169-409X</issn><issn>1872-8294</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNp9kM1qGzEUhUVJaVynL5BF0QNkJley5q-UQDBtEjB00Qa6E7J0lZEZS4M0NvjtK-MkNJustNA535E-Qi4ZlAxYfb0plTGx5MBEyVgJID6QGWsbXrS8E2dklkNdIaD7e04-p7QBYLyp4RM555UQNRMwI_7B92pAQ5WfXOG8RT25PVLd4zZMPUY1HqgNkUZMo4tqCvFAp6j0RJ_Dwadv9PdOa0wJ01VuqmFA_4QpMw3NDBqDygM9KnNBPlo1JPzyfM7J488ff5b3xerX3cPydlXoirOpsAq4qLq2gnXbCGUaaNZiYYTgvBVgdAtguVVsgXXXaARtDdYVtlYzFJUSizm5OXHH3XqLRqPPbx7kGN1WxYMMysm3N9718insZZ7oANoM4CeAjiGliPa1y0Ae7cuNPNqXR_uSMZnt59LX_1dfKy-6c-D7KYD573uHUSbt0Gs0LmaX0gT3Hv8fhFOZng</recordid><startdate>20150501</startdate><enddate>20150501</enddate><creator>Velkov, Tony</creator><creator>Abdul Rahim, Nusaibah</creator><creator>Zhou, Qi (Tony)</creator><creator>Chan, Hak-Kim</creator><creator>Li, Jian</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>20150501</creationdate><title>Inhaled anti-infective chemotherapy for respiratory tract infections: Successes, challenges and the road ahead</title><author>Velkov, Tony ; Abdul Rahim, Nusaibah ; Zhou, Qi (Tony) ; Chan, Hak-Kim ; Li, Jian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c521t-fa02459850b874ad707b43d4422840dc800f2fa13e697ce0cfde65e8fc1e45a43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Administration, Inhalation</topic><topic>Anti-Bacterial Agents - administration & dosage</topic><topic>Anti-Bacterial Agents - chemistry</topic><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>Antibiotics</topic><topic>Antifungal Agents - administration & dosage</topic><topic>Antifungal Agents - chemistry</topic><topic>Antifungal Agents - therapeutic use</topic><topic>Antifungals</topic><topic>Antiviral Agents - administration & dosage</topic><topic>Antiviral Agents - chemistry</topic><topic>Antiviral Agents - therapeutic use</topic><topic>Antivirals</topic><topic>Clinical Trials as Topic</topic><topic>Drug Delivery Systems - instrumentation</topic><topic>Drug Delivery Systems - methods</topic><topic>Humans</topic><topic>Inhalation</topic><topic>Molecular Structure</topic><topic>Pharmacokinetics/pharmacodynamics</topic><topic>Respiratory Tract Infections - drug therapy</topic><topic>Respiratory Tract Infections - microbiology</topic><topic>Respiratory Tract Infections - virology</topic><topic>Safety</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Velkov, Tony</creatorcontrib><creatorcontrib>Abdul Rahim, Nusaibah</creatorcontrib><creatorcontrib>Zhou, Qi (Tony)</creatorcontrib><creatorcontrib>Chan, Hak-Kim</creatorcontrib><creatorcontrib>Li, Jian</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Advanced drug delivery reviews</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Velkov, Tony</au><au>Abdul Rahim, Nusaibah</au><au>Zhou, Qi (Tony)</au><au>Chan, Hak-Kim</au><au>Li, Jian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inhaled anti-infective chemotherapy for respiratory tract infections: Successes, challenges and the road ahead</atitle><jtitle>Advanced drug delivery reviews</jtitle><addtitle>Adv Drug Deliv Rev</addtitle><date>2015-05-01</date><risdate>2015</risdate><volume>85</volume><spage>65</spage><epage>82</epage><pages>65-82</pages><issn>0169-409X</issn><eissn>1872-8294</eissn><abstract>One of the most common causes of illnesses in humans is from respiratory tract infections caused by bacterial, viral or fungal pathogens. Inhaled anti-infective drugs are crucial for the prophylaxis and treatment of respiratory tract infections. The benefit of anti-infective drug delivery via inhalation is that it affords delivery of sufficient therapeutic dosages directly to the primary site of infection, while minimizing the risks of systemic toxicity or avoiding potential suboptimal pharmacokinetics/pharmacodynamics associated with systemic drug exposure. This review provides an up-to-date treatise of approved and novel developmental inhaled anti-infective agents, with particular attention to effective strategies for their use, pulmonary pharmacokinetic properties and safety.
[Display omitted]</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>25446140</pmid><doi>10.1016/j.addr.2014.11.004</doi><tpages>18</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0169-409X |
| ispartof | Advanced drug delivery reviews, 2015-05, Vol.85, p.65-82 |
| issn | 0169-409X 1872-8294 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4429008 |
| source | ScienceDirect Freedom Collection |
| subjects | Administration, Inhalation Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - therapeutic use Antibiotics Antifungal Agents - administration & dosage Antifungal Agents - chemistry Antifungal Agents - therapeutic use Antifungals Antiviral Agents - administration & dosage Antiviral Agents - chemistry Antiviral Agents - therapeutic use Antivirals Clinical Trials as Topic Drug Delivery Systems - instrumentation Drug Delivery Systems - methods Humans Inhalation Molecular Structure Pharmacokinetics/pharmacodynamics Respiratory Tract Infections - drug therapy Respiratory Tract Infections - microbiology Respiratory Tract Infections - virology Safety |
| title | Inhaled anti-infective chemotherapy for respiratory tract infections: Successes, challenges and the road ahead |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T20%3A16%3A15IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-elsevier_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Inhaled%20anti-infective%20chemotherapy%20for%20respiratory%20tract%20infections:%20Successes,%20challenges%20and%20the%20road%20ahead&rft.jtitle=Advanced%20drug%20delivery%20reviews&rft.au=Velkov,%20Tony&rft.date=2015-05-01&rft.volume=85&rft.spage=65&rft.epage=82&rft.pages=65-82&rft.issn=0169-409X&rft.eissn=1872-8294&rft_id=info:doi/10.1016/j.addr.2014.11.004&rft_dat=%3Celsevier_pubme%3ES0169409X14002671%3C/elsevier_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c521t-fa02459850b874ad707b43d4422840dc800f2fa13e697ce0cfde65e8fc1e45a43%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_id=info:pmid/25446140&rfr_iscdi=true |