Systemic oxidative stress could predict assisted reproductive technique outcome

Purpose Previous studies have indicated that OxS (oxidative stress) may appear as a possible reason for poor ART outcome. Our aim was to study OxS levels in both partners of couples seeking Assisted reproduction Technology (ART). Methods Altogether 79 couples were recruited. Oxidative DNA damage (8-...

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Bibliographic Details
Published in:Journal of assisted reproduction and genetics 2015-05, Vol.32 (5), p.699-704
Main Authors: Ahelik, A., Mändar, R., Korrovits, P., Karits, P., Talving, E., Rosenstein, K., Jaagura, M., Salumets, A., Kullisaar, T.
Format: Article
Language:English
Subjects:
Adult
Assisted Reproduction Technologies
Biomarkers - analysis
Couples
Dinoprost - analogs & derivatives
Dinoprost - analysis
DNA Damage
Embryos
Female
Fertility
Fertilization in Vitro - methods
Gynecology
Human Genetics
Humans
In vitro fertilization
Infections
Infertility
Infertility - diagnosis
Infertility - etiology
Infertility - metabolism
Lipid Peroxidation
Lipids
Male
Medicine
Medicine & Public Health
Oxidative Stress
Pregnancy
Pregnancy Outcome
Reproductive Medicine
Reproductive Techniques, Assisted - adverse effects
Semen Analysis
Sperm
Urinalysis
Urine
Vagina
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Summary:Purpose Previous studies have indicated that OxS (oxidative stress) may appear as a possible reason for poor ART outcome. Our aim was to study OxS levels in both partners of couples seeking Assisted reproduction Technology (ART). Methods Altogether 79 couples were recruited. Oxidative DNA damage (8-OHdG) and lipid peroxidation (8-EPI) were measured, and clinical background and ART outcomes were recorded. Results Both OxS markers accurately reflected clincal conditions with prominent negative effects attributable to genital tract infections, endometriosis, uterine myoma and smoking. Furthermore, the level of OxS was also affected by partner’s state of health. The highest 8-EPI levels were detected in both partners when biochemically detectable pregnancies did not develop into clinically detectable pregnancies (in women, 97,8 ± 16,7 vs 72.9 ± 22,9, p  = 0.007; in men, 89.6 ± 20,4 vs 72,1 ± 22,6, p  = 0.049). Conclusions To conclude, high grade systemix OxS in both partners may negatively affect the maintenance and outcome of pregnancy. Applying the detection of OxS in ART patients may select patients with higher success rate and/or those who require antioxidant therapy. This would lead to improvement of ART outcome as well as natural fertility.
ISSN:1058-0468
1573-7330
DOI:10.1007/s10815-015-0466-6