Ret oncogene activation in human thyroid neoplasms is restricted to the papillary cancer subtype

We have recently reported the activation of a new oncogene in human papillary thyroid carcinomas. This oncogene, papillary thyroid carcinoma (PTC), is a novel rearranged version of the ret tyrosine-kinase protooncogene. Thyroid neoplasms include a broad spectrum of malignant tumors, ranging from wel...

Full description

Saved in:
Bibliographic Details
Published in:The Journal of clinical investigation 1992-05, Vol.89 (5), p.1517-1522
Main Authors: SANTORO, M, CARLOMAGNO, F, PEIX, J. L, PAULIN, C, FABIEN, N, VECCHIO, G, JENKINS, R. B, FUSCO, A, HAY, I. D, HERRMANN, M. A, GRIECO, M, MELILLO, R, PIEROTTI, M. A, BONGARZONE, I, DELLA PORTA, G, BERGER, N
Format: Article
Language:English
Subjects:
activation
Base Sequence
Biological and medical sciences
Blotting, Southern
carcinoma
Carcinoma, Papillary - genetics
Cell Transformation, Neoplastic - genetics
DNA, Neoplasm - genetics
Drosophila Proteins
Endocrinopathies
frequency
Gene Expression
Gene Rearrangement
Humans
Malignant tumors
man
Medical sciences
Molecular Sequence Data
Oncogenes
Polymerase Chain Reaction
Proto-Oncogene Proteins - genetics
Proto-Oncogene Proteins c-ret
Receptor Protein-Tyrosine Kinases
Restriction Mapping
ret
ret gene
RNA, Messenger - genetics
RNA, Neoplasm - genetics
thyroid
Thyroid Neoplasms - genetics
Thyroid Neoplasms - pathology
Thyroid. Thyroid axis (diseases)
Transfection
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We have recently reported the activation of a new oncogene in human papillary thyroid carcinomas. This oncogene, papillary thyroid carcinoma (PTC), is a novel rearranged version of the ret tyrosine-kinase protooncogene. Thyroid neoplasms include a broad spectrum of malignant tumors, ranging from well-differentiated tumors to undifferentiated anaplastic carcinomas. To determine the frequency of ret oncogene activation, we analyzed 286 cases of human thyroid tumors of diverse histologic types. We found the presence of an activated form of the ret oncogene in 33 (19%) of 177 papillary carcinomas. By contrast, none of the other 109 thyroid tumors, which included 37 follicular, 15 anaplastic, and 18 medullary carcinomas, and 34 benign lesions, showed ret activation.
ISSN:0021-9738
1558-8238
DOI:10.1172/jci115743