High Mortality Among Non-HIV-Infected People Who Inject Drugs in Bangkok, Thailand, 2005-2012

We examined the causes of hospitalization and death of people who inject drugs participating in the Bangkok Tenofovir Study, an HIV preexposure prophylaxis trial. The Bangkok Tenofovir Study was a randomized, double-blind, placebo-controlled trial conducted during 2005 to 2012 among 2413 people who...

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Bibliographic Details
Published in:American journal of public health (1971) 2015-06, Vol.105 (6), p.1136-1141
Main Authors: Vanichseni, Suphak, Martin, Michael, Suntharasamai, Pravan, Sangkum, Udomsak, Mock, Philip A, Gvetadze, Roman J, Curlin, Marcel E, Leethochawalit, Manoj, Chiamwongpaet, Sithisat, Chaipung, Benjamaporn, McNicholl, Janet M, Paxton, Lynn A, Kittimunkong, Somyot, Choopanya, Kachit
Format: Article
Language:English
Subjects:
Accidents, Traffic - mortality
Addictive behaviors
Adenine - administration & dosage
Adenine - analogs & derivatives
Adult
Alcohol
Anti-HIV Agents - administration & dosage
Autopsies
Cancer
Cause of Death
Counseling
Death & dying
Disease prevention
Double-Blind Method
Drug abuse
Drug overdose
Drug Overdose - mortality
Drugs
Enrollments
Epidemiology
Fatalities
Female
Global Health
HIV
HIV Infections - prevention & control
Hospitalization
Human immunodeficiency virus
Humans
Imprisonment
Infections
Kaplan-Meier Estimate
Laboratories
Male
Medical records
Methadone
Methamphetamine
Middle Aged
Morbidity
Mortality
Needle Sharing
Organophosphonates - administration & dosage
Population
Pre-Exposure Prophylaxis
Prevention
Public health
Research and Practice
Risk-Taking
Sepsis
Studies
Substance Abuse, Intravenous - mortality
Surveys and Questionnaires
Tenofovir
Thailand - epidemiology
Traffic accidents & safety
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Summary:We examined the causes of hospitalization and death of people who inject drugs participating in the Bangkok Tenofovir Study, an HIV preexposure prophylaxis trial. The Bangkok Tenofovir Study was a randomized, double-blind, placebo-controlled trial conducted during 2005 to 2012 among 2413 people who inject drugs. We reviewed medical records to define the causes of hospitalization and death, examined participant characteristics and risk behaviors to determine predictors of death, and compared the participant mortality rate with the rate of the general population of Bangkok, Thailand. Participants were followed an average of 4 years; 107 died: 22 (20.6%) from overdose, 13 (12.2%) from traffic accidents, and 12 (11.2%) from sepsis. In multivariable analysis, older age (40-59 years; P = .001), injecting drugs (P = .03), and injecting midazolam (P 
ISSN:0090-0036
1541-0048
DOI:10.2105/AJPH.2014.302473