Timing of menarche related to carotid artery intima-media thickness in black and white young adult women: the Bogalusa Heart Study

Abstract Purpose The early onset of menarche is related to the adulthood risk of cardiovascular (CV) disease. This study examines the relation of early onset of menarche to carotid artery intima-media thickness (IMT), which is a surrogate marker of CV disease, among asymptomatic young adult women in...

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Bibliographic Details
Published in:Annals of epidemiology 2015-06, Vol.25 (6), p.414-419
Main Authors: Bhuiyan, Azad R., PhD, MD, MPH, Srinivasan, Sathanur R., PhD, Chen, Wei, MD, PhD, Fernandez, Camilo, MD, MS, Xu, Ji-Hua, MD, Berenson, Gerald S., MD
Format: Article
Language:English
Subjects:
Adult
Age Factors
Black or African American
Carotid Arteries - diagnostic imaging
Carotid Intima-Media Thickness
Early onset of menarche
Female
Humans
Internal carotid artery intima-media thickness
Internal Medicine
Linear Models
Menarche
Waist-Height Ratio
White People
Young Adult
Young adult women
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Summary:Abstract Purpose The early onset of menarche is related to the adulthood risk of cardiovascular (CV) disease. This study examines the relation of early onset of menarche to carotid artery intima-media thickness (IMT), which is a surrogate marker of CV disease, among asymptomatic young adult women in a black-white community. Methods A cohort of 461 women (31% black, 69% white) aged 24 to 43 years (mean of 35.6 years) were participants in the Bogalusa Heart Study. The age at menarche was retrospectively collected. In addition to CV risk factor variable measurements B-mode ultrasound images of the far walls of carotid artery segments were obtained. The multivariate linear regression model along with mediating effect by Sobel test was applied to analyze menarcheal age effect on carotid artery IMT, adjusting for covariates. Results Waist to height ratio was significantly greater ( P  = .01) in early menarcheal age (
ISSN:1047-2797
1873-2585
DOI:10.1016/j.annepidem.2015.02.001