Headache in a young woman: leptomeningeal metastasis as the first presentation of underlying breast malignancy

A 37-year-old woman presented with a 2-week history of persistent headache in an occipitotemporal distribution. The patient had experienced prior headaches and migraines, but this presentation was characterised by its intensity and duration. There was associated dizziness and blurring of vision in e...

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Bibliographic Details
Published in:BMJ case reports 2015-05, Vol.2015, p.bcr2014207643
Main Authors: Mohan, Poornima, Antonelou, Marilina, Dadzie, Ophelia, Dubrey, Simon
Format: Article
Language:English
Subjects:
Adenocarcinoma - complications
Adenocarcinoma - diagnosis
Adenocarcinoma - secondary
Adenocarcinoma - therapy
Adult
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Biomarkers
Breast Neoplasms - pathology
Breasts
Cellular biology
Chemotherapy
Cranial Irradiation
Epilepsies, Partial - etiology
Facial Paralysis - etiology
Fatal Outcome
Female
Flow cytometry
Headache - etiology
Headaches
Humans
Lymphocytes
Magnetic Resonance Imaging
Mammography
Medical imaging
Medical prognosis
Meningeal Neoplasms - complications
Meningeal Neoplasms - diagnosis
Meningeal Neoplasms - secondary
Meningeal Neoplasms - therapy
Metastasis
Palliative care
Palliative Care - methods
Patients
Positron-Emission Tomography
Quality of life
Radiation therapy
Tomography, X-Ray Computed
United Kingdom
Unusual Presentation of More Common Disease/Injury
White
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Summary:A 37-year-old woman presented with a 2-week history of persistent headache in an occipitotemporal distribution. The patient had experienced prior headaches and migraines, but this presentation was characterised by its intensity and duration. There was associated dizziness and blurring of vision in episodes occurring up to 4–5 times per day. Whole body cross-sectional CT imaging and MRI of neuronal axes were normal. Cerebrospinal fluid cytology demonstrated large abnormal pleomorphic cells expressing the tumour marker CA125. Positron emission tomography-fluorodeoxyglucose revealed bilateral axillary and cervical lymphadenopathy as well as increased uptake in the lateral regions of both breasts. These results correlated with MRI breast and mammography findings. Axillary lymph node biopsy showed poorly differentiated adenocarcinoma making the diagnosis of breast malignancy, the most likely primary site of metastatic leptomeningeal disease. In the 6-week interval between initial presentation and diagnosis, the patient deteriorated significantly with the new onset of facial nerve palsy and partial seizures. The treatment intent was palliative, focusing on symptom control with systemic chemotherapy and whole brain radiotherapy.
ISSN:1757-790X
1757-790X
DOI:10.1136/bcr-2014-207643