Interaction models of CYP1A1, GSTM1 polymorphisms and tobacco smoking in intestinal gastric cancer

To explore the interaction models of the cytochrome P-450 (CYP) 1A1 Val variant and glutathione S-transferase (GST) M1 null polymorphisms with tobacco smoking in the occurrence of intestinal gastric cancer. A community-based case-control study was conducted in Yangzhong. Subjects included 114 intest...

Full description

Saved in:
Bibliographic Details
Published in:World journal of gastroenterology : WJG 2005-10, Vol.11 (38), p.6056-6060
Main Authors: Shen, Jing, Wang, Run-Tian, Xu, Yao-Chu, Wang, Li-Wei, Wang, Xin-Ru
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Asian Continental Ancestry Group - genetics
Brief Reports
Case-Control Studies
China
Cocarcinogenesis
Cytochrome P-450 CYP1A1 - genetics
Female
Glutathione Transferase - genetics
Humans
Male
Middle Aged
Models, Biological
Polymorphism, Genetic
Smoking - adverse effects
Stomach Neoplasms - enzymology
Stomach Neoplasms - etiology
Stomach Neoplasms - genetics
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:To explore the interaction models of the cytochrome P-450 (CYP) 1A1 Val variant and glutathione S-transferase (GST) M1 null polymorphisms with tobacco smoking in the occurrence of intestinal gastric cancer. A community-based case-control study was conducted in Yangzhong. Subjects included 114 intestinal types of gastric cancer with endoscopic and pathological diagnosis during January 1997 and December 1998, and 693 controls selected from their spouse, siblings or siblings-in-law who had no history of digestive system cancer. Logistic regression was used to estimate the interaction models. The frequency of the CYP1A1 Val variant allele in cases did not differ from that in controls. The OR of GSTM1 null genotype was 2.0 (95% confidence interval (95%CI): 1.2-3.1, P
ISSN:1007-9327
2219-2840
DOI:10.3748/wjg.v11.i38.6056