Preservation of tumor-host immune interactions with luciferase-tagged imaging in a murine model of ovarian cancer

Ovarian cancer is immunogenic and residual tumor volume after surgery is known to be prognostic. Ovarian cancer often follows a recurring-remitting course and microscopic disease states may present ideal opportunities for immune therapies. We sought to establish the immune profile of a murine model...

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Bibliographic Details
Published in:Journal for immunotherapy of cancer 2015-05, Vol.3 (1), p.16-16, Article 16
Main Authors: Liao, John B, Ovenell, Kelsie J, Curtis, Erin E M, Cecil, Denise L, Koehnlein, Marlese R, Rastetter, Lauren R, Gad, Ekram A, Disis, Mary L
Format: Article
Language:English
Subjects:
Albinism
Antigens
Cancer
Care and treatment
Codon
Immune response
Immunotherapy
Laboratories
Luciferase
Lymphocytes
Medical prognosis
Mutation
Ovarian cancer
T cells
Tumors
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Summary:Ovarian cancer is immunogenic and residual tumor volume after surgery is known to be prognostic. Ovarian cancer often follows a recurring-remitting course and microscopic disease states may present ideal opportunities for immune therapies. We sought to establish the immune profile of a murine model of ovarian cancer that allows in vivo tumor imaging and the quantitation of microscopic disease. Baseline imaging and weight measurements were taken within 1 and 2 weeks after intraperitoneal tumor injection, respectively. Significantly higher photons per second from baseline imaging were first observed 5 weeks after tumor cell injection (p 
ISSN:2051-1426
2051-1426
DOI:10.1186/s40425-015-0060-6