Indian Hedgehog signaling pathway members are associated with magnetic resonance imaging manifestations and pathological scores in lumbar facet joint osteoarthritis

Indian Hedgehog (HH) has been shown to be involved in osteoarthritis (OA) in articular joints, where there is evidence that Indian HH blockade could ameliorate OA. It seems to play a prominent role in development of the intervertebral disc (IVD) and in postnatal maintenance. There is little work on...

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Bibliographic Details
Published in:Scientific reports 2015-05, Vol.5 (1), p.10290-10290, Article 10290
Main Authors: Shuang, Feng, Zhou, Ying, Hou, Shu-Xun, Zhu, Jia-Liang, Liu, Yan, Zhang, Chun-Li, Tang, Jia-Guang
Format: Article
Language:English
Subjects:
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Adult
Aged
Arthritis
Carrier Proteins - genetics
Carrier Proteins - metabolism
Female
Hedgehog protein
Hedgehog Proteins - metabolism
Histopathology
Humanities and Social Sciences
Humans
Intervertebral Disc - pathology
Intervertebral discs
Magnetic Resonance Imaging
Male
Membrane Glycoproteins - genetics
Membrane Glycoproteins - metabolism
Middle Aged
mRNA
multidisciplinary
NMR
Nuclear magnetic resonance
Osteoarthritis
Osteoarthritis - diagnostic imaging
Osteoarthritis - metabolism
Osteoarthritis - pathology
Patched Receptors
Patched-1 Receptor
Radiography
Real-Time Polymerase Chain Reaction
Receptors, Cell Surface - genetics
Receptors, Cell Surface - metabolism
RNA, Messenger - metabolism
Science
Severity of Illness Index
Signal Transduction
Spinal stenosis
Transcription Factors - genetics
Transcription Factors - metabolism
Zinc Finger Protein GLI1
Zygapophyseal Joint - diagnostic imaging
Zygapophyseal Joint - metabolism
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Summary:Indian Hedgehog (HH) has been shown to be involved in osteoarthritis (OA) in articular joints, where there is evidence that Indian HH blockade could ameliorate OA. It seems to play a prominent role in development of the intervertebral disc (IVD) and in postnatal maintenance. There is little work on IHH in the IVD. Hence the aim of the current study was to investigate the role of Indian Hedgehog in the pathology of facet joint (FJ) OA. 24 patients diagnosed with lumbar intervertebral disk herniation or degenerative spinal stenosis were included. Preoperative magnetic resonance imaging (MRI) and Osteoarthritis Research Society International (OARSI) histopathology grading system was correlated to the mRNA levels of GLI1 , PTCH1 and HHIP in the FJs. The Weishaupt grading and OARSI scores showed high positive correlation (r = 0.894) ( P  
ISSN:2045-2322
2045-2322
DOI:10.1038/srep10290