Neutrophil extracellular traps in physiology and pathology

Neutrophil extracellular traps (NETs) are developed by nature to protect the body from furious invaders. On the other hand NET s can play an important role in human pathology. Recent studies have shown that neutrophils are able to perform beneficial suicide to create an unique microbicidal net compo...

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Bibliographic Details
Published in:Central-European journal of immunology 2014, Vol.39 (1), p.116-121
Main Authors: Manda, Aneta, Pruchniak, Michał P, Araźna, Magdalena, Demkow, Urszula A
Format: Article
Language:English
Subjects:
Review
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Summary:Neutrophil extracellular traps (NETs) are developed by nature to protect the body from furious invaders. On the other hand NET s can play an important role in human pathology. Recent studies have shown that neutrophils are able to perform beneficial suicide to create an unique microbicidal net composed from cellular content attached to chromatic frame. It is a powerful tool that primary serve as protector from severe infections, but this weapon is also a double ended sword of the immunity. If overproduced NET s provoke certain autoimmune diseases, coagulation disorders and even cancer metastases. Moreover, due to the competition between host and pathogens, the microorganism have developed a width repertoire of sophisticated evading mechanisms, like creation of polysaccharide capsule or changes in cell wall charge. Therefore it is important to increase the knowledge about paths underlying NET s formation and degradation processes if we want to efficiently fight with bacterial infections and certain diseases.
ISSN:1426-3912
1644-4124
DOI:10.5114/ceji.2014.42136