Identification of functional tag single nucleotide polmorphisms within the entire CAT gene and their clinical relevance in patients with noise-induced hearing loss

Noise-induced hearing loss (NIHL) is an important occupational disease which results from an interaction between genetic and environmental factors. More and more evidences suggested that Catalase (CAT) gene polymorphism plays an important role in the development of NIHL. The aim of this study was to...

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Published in:International journal of clinical and experimental pathology 2015-01, Vol.8 (3), p.2852-2863
Main Authors: Yang, Junhui, Zhang, Jieyuan, Wang, Xiaoming, Wang, Chaoyong, Chen, Jichuan, Qian, Yu, Duan, Zhaoxia
Format: Article
Language:English
Subjects:
Adolescent
Adult
Asian Continental Ancestry Group - genetics
Audiometry, Pure-Tone
Case-Control Studies
Catalase - genetics
Enzyme-Linked Immunosorbent Assay
Female
Genetic Predisposition to Disease - genetics
Genotype
Hearing Loss, Noise-Induced - genetics
Humans
Male
Middle Aged
Occupational Diseases - genetics
Original
Polymorphism, Single Nucleotide
Young Adult
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container_title International journal of clinical and experimental pathology
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creator Yang, Junhui
Zhang, Jieyuan
Wang, Xiaoming
Wang, Chaoyong
Chen, Jichuan
Qian, Yu
Duan, Zhaoxia
description Noise-induced hearing loss (NIHL) is an important occupational disease which results from an interaction between genetic and environmental factors. More and more evidences suggested that Catalase (CAT) gene polymorphism plays an important role in the development of NIHL. The aim of this study was to investigate the association of CAT gene polymorphisms with NIHL in a case-control study. A total of 719 unrelated adult Chinese Han population, including 225 healthy volunteers and 494 noise-exposed workers were recruited in this study. Six tag single-nucleotide polymorphisms (tSNPs) were genotyped using an improved multiplex ligation detection reaction technique. Subsequently, the interaction between noise exposure level and genotypes and their effect on NIHL were analyzed using logistic regression. Among six tSNPs, two of them (rs208679 and rs769217) were significantly associated with noise exposure level. For rs208679 recessive effect, GG genotype had a significantly increased of NIHL risk in the exposure level of
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More and more evidences suggested that Catalase (CAT) gene polymorphism plays an important role in the development of NIHL. The aim of this study was to investigate the association of CAT gene polymorphisms with NIHL in a case-control study. A total of 719 unrelated adult Chinese Han population, including 225 healthy volunteers and 494 noise-exposed workers were recruited in this study. Six tag single-nucleotide polymorphisms (tSNPs) were genotyped using an improved multiplex ligation detection reaction technique. Subsequently, the interaction between noise exposure level and genotypes and their effect on NIHL were analyzed using logistic regression. Among six tSNPs, two of them (rs208679 and rs769217) were significantly associated with noise exposure level. For rs208679 recessive effect, GG genotype had a significantly increased of NIHL risk in the exposure level of &lt;85 dB; and for rs769217 dominant effect, the combined genotypes TT/TC had a significantly increased of NIHL risk in the exposure level of 85 dB~92 dB; and the haplotype A-G-T-C-A-C had a risk effect on the NIHL in the exposure level of 85 dB~92 dB. In addition, the rs769217 polymorphism could enhance the transcription activities of the CAT gene. This study identified CAT is a NIHL susceptibility gene when noise exposure levels are taken into account. 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More and more evidences suggested that Catalase (CAT) gene polymorphism plays an important role in the development of NIHL. The aim of this study was to investigate the association of CAT gene polymorphisms with NIHL in a case-control study. A total of 719 unrelated adult Chinese Han population, including 225 healthy volunteers and 494 noise-exposed workers were recruited in this study. Six tag single-nucleotide polymorphisms (tSNPs) were genotyped using an improved multiplex ligation detection reaction technique. Subsequently, the interaction between noise exposure level and genotypes and their effect on NIHL were analyzed using logistic regression. Among six tSNPs, two of them (rs208679 and rs769217) were significantly associated with noise exposure level. For rs208679 recessive effect, GG genotype had a significantly increased of NIHL risk in the exposure level of &lt;85 dB; and for rs769217 dominant effect, the combined genotypes TT/TC had a significantly increased of NIHL risk in the exposure level of 85 dB~92 dB; and the haplotype A-G-T-C-A-C had a risk effect on the NIHL in the exposure level of 85 dB~92 dB. In addition, the rs769217 polymorphism could enhance the transcription activities of the CAT gene. This study identified CAT is a NIHL susceptibility gene when noise exposure levels are taken into account. Rs208679 and rs769217 polymorphisms might be used as relevant risk estimates for the development of NIHL in population with different noise exposure levels.</abstract><cop>United States</cop><pub>e-Century Publishing Corporation</pub><pmid>26045794</pmid><tpages>12</tpages></addata></record>
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subjects Adolescent
Adult
Asian Continental Ancestry Group - genetics
Audiometry, Pure-Tone
Case-Control Studies
Catalase - genetics
Enzyme-Linked Immunosorbent Assay
Female
Genetic Predisposition to Disease - genetics
Genotype
Hearing Loss, Noise-Induced - genetics
Humans
Male
Middle Aged
Occupational Diseases - genetics
Original
Polymorphism, Single Nucleotide
Young Adult
title Identification of functional tag single nucleotide polmorphisms within the entire CAT gene and their clinical relevance in patients with noise-induced hearing loss
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