Mechanisms involved in breast cancer liver metastasis

Liver metastasis is a frequent occurrence in patients with breast cancer; however, the available treatments are limited and ineffective. While liver-specific homing of breast cancer cells is an important feature of metastasis, the formation of liver metastases is not random. Indeed, breast cancer ce...

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Bibliographic Details
Published in:Journal of translational medicine 2015-02, Vol.13 (1), p.64-64, Article 64
Main Authors: Ma, Rui, Feng, Yili, Lin, Shuang, Chen, Jiang, Lin, Hui, Liang, Xiao, Zheng, Heming, Cai, Xiujun
Format: Article
Language:English
Subjects:
Breast Neoplasms - metabolism
Breast Neoplasms - pathology
Female
Humans
Liver Neoplasms - secondary
Models, Biological
Neoplasm Metastasis - pathology
Neoplasm Proteins - metabolism
Review
Tumor Microenvironment
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Summary:Liver metastasis is a frequent occurrence in patients with breast cancer; however, the available treatments are limited and ineffective. While liver-specific homing of breast cancer cells is an important feature of metastasis, the formation of liver metastases is not random. Indeed, breast cancer cell factors contribute to the liver microenvironment. Major breakthroughs have been achieved recently in understanding breast cancer liver metastasis (BCLM). The process of liver metastasis consists of multiple steps and involves various factors from breast cancer cells and the liver microenvironment. A further understanding of the roles of breast cancer cells and the liver microenvironment is crucial to guide future work in clinical treatments. In this review we discuss the contribution of breast cancer cells and the liver microenvironment to liver metastasis, with the aim to improve therapeutic efficacy for patients with BCLM.
ISSN:1479-5876
1479-5876
DOI:10.1186/s12967-015-0425-0