Heroin Use and HIV Disease Progression: Results from a Pilot Study of a Russian Cohort

Opioids have immunosuppressive properties, yet their impact on HIV disease progression remains unclear. Using longitudinal data from HIV-infected antiretroviral therapy-naïve Russian individuals (n = 77), we conducted a pilot study to estimate the effect of heroin use on HIV disease progression. Her...

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Bibliographic Details
Published in:AIDS and behavior 2015-06, Vol.19 (6), p.1089-1097
Main Authors: Edelman, E. Jennifer, Cheng, Debbie M., Krupitsky, Evgeny M., Bridden, Carly, Quinn, Emily, Walley, Alexander Y., Lioznov, Dmitry A., Blokhina, Elena, Zvartau, Edwin, Samet, Jeffrey H.
Format: Article
Language:English
Subjects:
Acquired immune deficiency syndrome
Adult
AIDS
Anti-HIV Agents - therapeutic use
Antiretroviral agents
Antiretroviral therapy
CD4 antigen
CD4 Lymphocyte Count - statistics & numerical data
Disease Progression
Drug abuse
Drugs
Female
Health Psychology
Heroin
Heroin Dependence - complications
Heroin Dependence - epidemiology
HIV
HIV Infections - complications
HIV Infections - drug therapy
HIV Infections - epidemiology
HIV Infections - virology
Human immunodeficiency virus
Humans
Infectious Diseases
Longitudinal Studies
Male
Medicine
Medicine & Public Health
Multivariate Analysis
Narcotics
Opiates
Original Paper
Pilot Projects
Prevalence
Public Health
Regression Analysis
Risk Factors
Russia - epidemiology
Socioeconomic Factors
Studies
Viral Load - drug effects
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Summary:Opioids have immunosuppressive properties, yet their impact on HIV disease progression remains unclear. Using longitudinal data from HIV-infected antiretroviral therapy-naïve Russian individuals (n = 77), we conducted a pilot study to estimate the effect of heroin use on HIV disease progression. Heroin use was categorized based on past 30 days self-reported use at baseline, 6 and 12 months as none, intermittent or persistent. We estimated the effect of heroin use on HIV disease progression, measured as change in CD4 count from baseline to 12 months, using multivariable linear regression. Those with intermittent (n = 21) and no heroin use (n = 39) experienced mean decreases in CD4 count from baseline to 12 months (−103 and −10 cells/mm 3 , respectively; adjusted mean difference (AMD) −93; 95 % CI −245, 58). Those with persistent use (n = 17) showed a mean increase of 53 cells/mm 3 (AMD 63; 95 % CI −95, 220). Future studies exploring the effects of heroin withdrawal on HIV disease progression are warranted.
ISSN:1090-7165
1573-3254
DOI:10.1007/s10461-014-0948-z