Effects of bariatric surgery on incidence of obesity-related cancers: a meta-analysis

The aim of this meta-analysis was to investigate possible relationships between bariatric surgery and incidence of obesity-related cancers. Obesity is an established risk factor for obesity-related cancers but the effects of bariatric surgery on incidence of obesity-related cancers are uncertain. We...

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Bibliographic Details
Published in:Medical science monitor 2015-05, Vol.21, p.1350-1357
Main Authors: Yang, Xiang-wu, Li, Peng-zhou, Zhu, Li-yong, Zhu, Shaihong
Format: Article
Language:English
Subjects:
Bariatric Surgery
Cohort Studies
Colorectal Neoplasms - epidemiology
Colorectal Neoplasms - etiology
Colorectal Neoplasms - prevention & control
Confounding Factors (Epidemiology)
Data Accuracy
Disease Susceptibility
Female
Humans
Incidence
Male
Meta-Analysis
Neoplasms - epidemiology
Neoplasms - etiology
Neoplasms - prevention & control
Obesity, Morbid - complications
Obesity, Morbid - surgery
Observational Studies as Topic - statistics & numerical data
Publication Bias
Retrospective Studies
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Summary:The aim of this meta-analysis was to investigate possible relationships between bariatric surgery and incidence of obesity-related cancers. Obesity is an established risk factor for obesity-related cancers but the effects of bariatric surgery on incidence of obesity-related cancers are uncertain. We searched 4 electronic databases to identify eligible studies: PubMed, Embase, Web of Science, and Google Scholar. Five observational studies were eligible and included in this meta-analysis. Random-effects or fixed-effects odds ratio (OR) and its corresponding 95% confidence interval (CI) were pooled. Meta-analysis of these 5 observational studies revealed that bariatric surgery was associated with a significantly (p=0.0004) reduced incidence of obesity-related cancers (OR=0.43, 95%CI, 0.27-0.69) when compared with control individuals. Pooled estimated data showed that bariatric surgery is associated with a 24% lower colorectal cancer (CRC) risk. No publication bias was detected by Egger's or Begg's tests. Although bariatric surgery may significantly reduce incidence of obesity-related cancers, considering the limitations of these included studies, these findings should be confirmed by further well-designed studies.
ISSN:1643-3750
1234-1010
1643-3750
DOI:10.12659/MSM.893553