The relative contribution of common and rare genetic variants to ADHD

Attention deficit hyperactivity disorder (ADHD) is highly heritable. Genome-wide molecular studies show an increased burden of large, rare copy-number variants (CNVs) in children with ADHD compared with controls. Recent polygenic risk score analyses have also shown that en masse common variants are...

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Bibliographic Details
Published in:Translational psychiatry 2015-02, Vol.5 (2), p.e506-e506
Main Authors: Martin, J, O'Donovan, M C, Thapar, A, Langley, K, Williams, N
Format: Article
Language:English
Subjects:
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631/208
Adolescent
Attention Deficit Disorder with Hyperactivity - genetics
Behavioral Sciences
Biological Psychology
Case-Control Studies
Child
DNA Copy Number Variations
Female
Genetic Predisposition to Disease
Humans
Male
Medicine
Medicine & Public Health
Multifactorial Inheritance - genetics
Neurosciences
Original
original-article
Pharmacotherapy
Polymorphism, Single Nucleotide
Psychiatry
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Summary:Attention deficit hyperactivity disorder (ADHD) is highly heritable. Genome-wide molecular studies show an increased burden of large, rare copy-number variants (CNVs) in children with ADHD compared with controls. Recent polygenic risk score analyses have also shown that en masse common variants are enriched in ADHD cases compared with population controls. The relationship between these common and rare variants has yet to be explored. In this study, we tested whether children with ADHD with ( N =60) a large (>500 kb), rare (
ISSN:2158-3188
2158-3188
DOI:10.1038/tp.2015.5