Recurrent myocardial infarction secondary to Prinzmetal's variant angina

Prinzmetal's variant angina describes chest pain secondary to reversible coronary artery vasospasm in the context of both diseased and non-diseased coronary arteries. Symptoms typically occur when the patient is at rest and are associated with transient ST-segment elevation. Acute episodes resp...

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Bibliographic Details
Published in:Singapore medical journal 2015-05, Vol.56 (5), p.e74-e77
Main Authors: Murdoch, Dale, Dhillon, Priyanka, Niranjan, Selvanayagam
Format: Article
Language:English
Subjects:
Adult
Angina Pectoris, Variant - complications
Angina Pectoris, Variant - drug therapy
Case Report
Constriction, Pathologic - drug therapy
Constriction, Pathologic - pathology
Coronary Angiography
Coronary Vasospasm
Coronary Vessels - physiopathology
Electrocardiography
Female
Humans
Myocardial Infarction - complications
Myocardial Infarction - drug therapy
Myocardial Infarction - pathology
Nitroglycerin - therapeutic use
Recurrence
Vasodilator Agents - therapeutic use
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Summary:Prinzmetal's variant angina describes chest pain secondary to reversible coronary artery vasospasm in the context of both diseased and non-diseased coronary arteries. Symptoms typically occur when the patient is at rest and are associated with transient ST-segment elevation. Acute episodes respond to glyceryl trinitrate, but myocardial infarction and other potentially fatal complications can occur, and long-term management can be challenging. Although it is not well understood, the underlying mechanism appears to involve a combination of endothelial damage and vasoactive mediators. In this case, a 35-year-old woman with myocardial infarction secondary to coronary artery vasospasm experienced recurrent chest pain. Coronary angiography revealed severe focal stenosis in the mid left anterior descending artery, which completely resolved after administration of intracoronary glyceryl trinitrate. The patient was discharged on nitrates and calcium channel blockers. The patient re-presented with another myocardial infarction, requiring up-titration of medical therapy.
ISSN:0037-5675
DOI:10.11622/smedj.2015077