Potential Peripartum Markers of Infectious-Inflammatory Complications in Spontaneous Preterm Birth

Spontaneous preterm birth significantly contributes to the overall neonatal morbidity associated with preterm deliveries. Nearly 50% of cases are associated with microbial invasion of the amniotic cavity followed by an inflammatory response. Robust diagnostic tools for neonates jeopardized by infect...

Full description

Saved in:
Bibliographic Details
Published in:BioMed research international 2015-01, Vol.2015 (2015), p.1-13
Main Authors: Lenco, Juraj, Domasinska, Petra, Link, Marek, Kacerovsky, Marian, Vajrychova, Marie, Tambor, Vojtech, Menon, Ramkumar
Format: Article
Language:English
Subjects:
Adult
Amniotic fluid
Amniotic Fluid - metabolism
Biomedical research
Childbirth & labor
Complications and side effects
Female
Fluids
Gynecology
Hospitals
Humans
Inflammation
Inflammation - complications
Inflammation - genetics
Mass spectrometry
Obstetrics
Peptide Mapping
Peripartum Period - genetics
Physiological aspects
Pregnancy
Pregnancy Complications, Infectious - genetics
Pregnancy Complications, Infectious - pathology
Premature birth
Premature Birth - genetics
Premature Birth - pathology
Proteins
Proteome - genetics
Review boards
Scientific imaging
Studies
Womens health
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Spontaneous preterm birth significantly contributes to the overall neonatal morbidity associated with preterm deliveries. Nearly 50% of cases are associated with microbial invasion of the amniotic cavity followed by an inflammatory response. Robust diagnostic tools for neonates jeopardized by infection and inflammation may thus decrease the overall neonatal morbidity substantially. Amniotic fluid retrieved during labor retains fetal and pregnancy-related protein fingerprint and its sampling does not place any unwanted stress on women. Using exploratory and targeted methods we analyzed proteomes of amniotic fluid sampled at the end of spontaneous preterm labor prior to delivery from women with and without infection and inflammation. Exploratory data indicated several amniotic fluid proteins to be associated with infectious-inflammatory complications in spontaneous preterm birth. LC-SRM analysis subsequently verified statistically significant changes in lipocalin-1 (P=0.047 and AUC = 0.67, P=0.046), glycodelin (P=0.013 and AUC = 0.73, P=0.013), and nicotinamide phosphoribosyltransferase (P=0.018 and AUC = 0.71, P=0.01).
ISSN:2314-6133
2314-6141
DOI:10.1155/2015/343501