Signals for pre-mRNA cleavage and polyadenylation

Pre‐mRNA cleavage and polyadenylation is an essential step for 3′ end formation of almost all protein‐coding transcripts in eukaryotes. The reaction, involving cleavage of nascent mRNA followed by addition of a polyadenylate or poly(A) tail, is controlled by cis‐acting elements in the pre‐mRNA surro...

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Published in:Wiley interdisciplinary reviews. RNA 2012-05, Vol.3 (3), p.385-396
Main Authors: Tian, Bin, Graber, Joel H.
Format: Article
Language:English
Subjects:
Animals
Computational Biology
Humans
mRNA Cleavage and Polyadenylation Factors - metabolism
Plants - genetics
Plants - metabolism
Poly A - chemistry
Poly A - metabolism
Polyadenine
Polyadenylation
Polynucleotide Adenylyltransferase - metabolism
Regulatory Sequences, Nucleic Acid
RNA Precursors - genetics
RNA Precursors - metabolism
RNA processing
Saccharomyces cerevisiae - genetics
Saccharomyces cerevisiae - metabolism
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Summary:Pre‐mRNA cleavage and polyadenylation is an essential step for 3′ end formation of almost all protein‐coding transcripts in eukaryotes. The reaction, involving cleavage of nascent mRNA followed by addition of a polyadenylate or poly(A) tail, is controlled by cis‐acting elements in the pre‐mRNA surrounding the cleavage site. Experimental and bioinformatic studies in the past three decades have elucidated conserved and divergent elements across eukaryotes, from yeast to human. Here we review histories and current models of these elements in a broad range of species. WIREs RNA 2012, 3:385–396. doi: 10.1002/wrna.116 This article is categorized under: RNA Processing > 3' End Processing
ISSN:1757-7004
1757-7012
DOI:10.1002/wrna.116